polyclonal tumors

[pathomatic]

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At the risk of sounding naive,

any e.g. of a single tumor mass of a polyclonal origin with tumor cells arising from two or more different progenitor cells with different translocations, deletions, different oncogene activation etc. etc.

Also, am I correct in assuming that most tumors are monoclonal in nature?

I would appreciate any input from the path veterans in this forum🙂

 

[DrBloodmoney]

How about collision tumors.

 

[pathdoc68]

Although neoplasia ususually starts out clonal, often subclones develop as the tumor grows. Tumor have inherrent genetic instability so there is lots of rearrangement, breaks and new mutations.

 

[djmd]

That's true Pathdoc, but OP is asking about some sort of CarcSarc, where multiple elements are separate neoplastic mutations/translocations...

CarcSarc (MMMT) is the closest I can think of, but it is really one process with a split differentiation, rather than "different progenitor cells with different translocations". There some other examples where tumors can drive a para/pseudo neoplastic response in other tissue, but that is still not two separate systems.