Post Splenectomy Infections

Discussion in 'Step I' started by Enzymes, May 16, 2014.

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  1. Enzymes

    Enzymes 2+ Year Member

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    Mar 13, 2012
    So I understand that the splenic macrophages are important for gobbling up opsonized bacteria in the blood. But in first aid, the mechanism for splenic dysfunction is: low IgM, decrease in complement, decrease in C3B opsonization (p. 197 2014). I don't understand where the low IgM is coming from. Any thoughts?
     
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  3. tantacles

    tantacles Lifetime Donor SDN Moderator 7+ Year Member

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    The spleen has tons of germinal centers. You're removing a huge center of antibody production.
     
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  4. Enzymes

    Enzymes 2+ Year Member

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    Mar 13, 2012
    Ah, so you are removing 2 mechanisms of pathogen removal: opsonization and phagocytosis. Thanks.
     

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