Post Splenectomy Infections

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Enzymes

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So I understand that the splenic macrophages are important for gobbling up opsonized bacteria in the blood. But in first aid, the mechanism for splenic dysfunction is: low IgM, decrease in complement, decrease in C3B opsonization (p. 197 2014). I don't understand where the low IgM is coming from. Any thoughts?

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So I understand that the splenic macrophages are important for gobbling up opsonized bacteria in the blood. But in first aid, the mechanism for splenic dysfunction is: low IgM, decrease in complement, decrease in C3B opsonization (p. 197 2014). I don't understand where the low IgM is coming from. Any thoughts?

The spleen has tons of germinal centers. You're removing a huge center of antibody production.
 
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