50% number among health care workers is alarming. What make them to think 2 vaccines FDA approved for EUA have insufficient clinical data?
Some concerns that I've heard about the vaccine:
1) The first Pfizer mRNA vaccine was not unanimously approved by the committee (17 in favor, 4 not in favor). Why did 4 people vote 'no'? Were there safety concerns that we needed to be aware of? As it turns out, those who voted 'no' did so primarily because the indication included 16 and 17 year olds, rather than just those 18 and older. Many people just read the headline, and did not dig that deeply.
2) Were the mRNA vaccines EUA approval based purely on science? In perhaps another example of the current administration sabotaging their own management of the COVID pandemic, it was widely reported that the White House had pressured the FDA chief to approve the vaccine by the end of the day or to resign. I suspect the vaccine would have been approved expeditiously either way, but such reports certainly did little to assuage concerns about political expediency in this process. Of course, this comes after the FDA's questionable approval of hydroxychloroquine for COVID use in the spring after our dear commander baselessly touted its efficacy (the EUA approval for hydroxychloroquine was later revoked), or how other COVID therapies such as remdesivir, convalescent plasma, and antibody therapies (bamlanivimab, casirivimab/imdevimab, among others) were similarly approved for EUA with really scant (and in some cases, laughable) clinical data, with still much debate about their efficacy amongst our ID specialists and intensivists. Recall that the WHO recently came out against use of remdesivir. As
@athorcommens pointed out, the FDA's track record is far from flawless.
3) What are the long-term benefits and risks of a mRNA-based vaccine? Unfortunately, this remains a big question mark in my mind as the original vaccine trials (through no fault of their own) only give us a few precious months of data. There remains many questions about the durability of its protection and theoretical risks from mRNA therapies that will need to be answered over the coming months and years.
Despite having some concerns myself, I opted to get the COVID-19 vaccine earlier this week. Yes, there are largely isolated reports of adverse reactions to the vaccine: some in Alaska had serious side effects, someone in Tennessee fainted on camera, etc., and yes, the long-term effects remain unknown as mentioned above. However, the choice was simple when weighing this against the high prevalence of COVID-19 in my community, the
18,000+(including some young healthy people) who have died in the same time period alone (1 week), not to mention the countless more who have lost productivity due to hospitalization and/or quarantine, AND the unknown long-term complications of COVID-19 (I'm particularly worried about its long-term vasculopathic effects). The calculus is far in favor of receiving the vaccine, and I strongly suspect that most people will come around as the short- and medium-term safety and efficacy of the vaccine are demonstrated.