It is easier in d-school if you majored in biology, perhaps chemistry or other science, but only because the material is not completely foreign to you. Are they going to skip things in the material or expect you to know certain things? Absoluety not. If you study hard, and you will probably hard to study a little harder than most at some things, you will do good, not just pass. So don't let this sway your decision.
As far as getting into d-school, the previous poster i agree with. If anything it will only give the interviewer a refreshment from the typical background they are use to, and they in no way hold it against you. It will actually give you something that makes you unique from everyone else, which is the name of the game as long as you can get a decent GPA & DAT score.