Pre-eclampsia .... Linking the symptoms

[Dark tar]

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Hello everyone,

I have a couple of question regarding pre-eclampsia.
1- can pre-eclampsia start with nephrotic syndrome then develop into ATN?
2- why is the liver involved in a (periportal ) fashion. If the problem is vasoconstriction and DIC wouldn't a (pericentral) necrosis make more sense??

Please help

 

[scoKraz4]

One of the defining characteristics of pre-eclampsia is >300mg protein in 24/h and nephrotic syndrome is i think >350mg protein in 24/h. So Most likely, yea you will have nephrotic syndrome before you start compromising blood supply to the tubules like in ATN.

I tried looking for an answer to your second question but cannot find anything. Maybe it isn't really known why it preferentially affects that area and it is just an observation?

 

[Dark tar]

One of the defining characteristics of pre-eclampsia is >300mg protein in 24/h and nephrotic syndrome is i think >350mg protein in 24/h. So Most likely, yea you will have nephrotic syndrome before you start compromising blood supply to the tubules like in ATN.

I tried looking for an answer to your second question but cannot find anything. Maybe it isn't really known why it preferentially affects that area and it is just an observation?

Thank you for participating. I have a logic in my head. That circulatory problems (ischemic) tend to effect the pericentral area of the liver since it has the least cut of the nutrients and O2. And toxic problems (like in drug toxicities) the necrosis effects the periportal area since it recieves the blood first. I couldn't make that work in the preeclampsia case. I think this syndrome is mostely not discovered fully yet.

 

[nowanmd]

good mnemonic pre eclampsia hep (hypertension,edema proteinuria) eclampsia hep c (hypertension,edema,proteinuria and convulsions)