Pressure and Atrophy

[MudPhud20XX]

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FA says increase in pressure such as due to nephrolithiasis can lead to atrophy of an organ in this case, I am assuming that they are referring to the kidney. Can anyone explain the mech here? Many thanks in advance.

 

[scoKraz4]

Increased pressure will close off vasculature in the organ-->cell death-->grossly appearing as organ atrophy

 

[PaxRoma]

Chronic nephrolithiasis -> increased tubular pressure -> vasa recta ischemia -> renal parenchyma injury -> atrophy (the kidney can look bigger itself because of hydronephrosis, but the renal parenchyma itself is atrophic)

 

[tasar1898]

All organs atrophy if you increase their pressures due to relative ischemia ( Reduced perfusion pressure ) . If its acute (e.g Toxic megacolon/Appendicitis ) you get necrosis and the organ gets $$$$ed up .. If its subacute ( pancreatic duct obstruction / nephrolithiasis / etc.. ) you get a mix of apoptosis/shrinking of cells --> Grossly looks like atrophy and the organ works sub optimally , or eventually , it doesn't work at all . Specifically in the kidney its like Pax Roma said , the cortex gets squeezed so it atrophies --> Glomeruli don't work , but the ducts/pelvis is filled up with urine , so it looks distended/big