problem based learning question

[erin682]

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My sister is taking an physiology class and has the following problem-based learning question

"A patient recieved general anesthesia and his heart rate increased, he had wide spread and strong muscle contractions throughout his body and is sweating profusely with rapid temperature increase. The anesthetic 'drug X' has produced a condition known as malignant hyperthermia. Where is most of the heat generated and what chemical reaction is responsible for generating the large amount of heat?"

Does anyone have any thoughts on this?

I appreciate the help.

 

[cytoskelement]

"Muscle contractions cause body temperature to rise" would be the obvious answer.

Malignant hyperthermia seems to be related to an Auto. dominant disorder in a ryanodine receptor which allows Ca release from the SR in response to certain drugs. I'd be willing to bet the a similar receptor appears in the hypothalamus or another area of the CNS that would change nerve conduction, etc.

just some thoughts...

 

[erin682]

🙂 thanks a lot for the help

 

[RAwe]

Malignant hyperthermia seems to be related to an Auto. dominant disorder in a ryanodine receptor which allows Ca release from the SR in response to certain drugs. I'd be willing to bet the a similar receptor appears in the hypothalamus or another area of the CNS that would change nerve conduction, etc.

Holy Crap! 😱 Damn I can't wait to be like this.
Just spit off answers to isht left and right

 

[omarsaleh66]

That anesthetic is Succinylcholine. Its a depolarizing block so what this does is that it hits your Ach receptors so hard (agonists) that they get tired and cant generate anymore Action Potentials and shut off. So this drug is used as a mucle relaxant during surgery to keep the muscles still while the surgeons operate.

WHat the above poster said is right. Skeletal muscle contractions can cause the hyperthermia and u would use DAntrolene to cool them down and I think Dantrolene blocks the Ryanitine receptor to offset this hyperthermia.