Procedure for adding LOR mid-cycle

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Hello,

What is the procedure for adding a new LOR during the middle of the cycle?

I was planning to send it to the schools that have not yet rejected me, including some at which I have interviewed at/may be on a waitlist. The letter is from the graduate medical science M.S program I am currently completing.

Do I simply add it on AMCAS and select the schools to send it to? Or do I need to email each individual school to ensure they have processed and added it to my file?
I would only send this to schools which have indicated they will accept one.
Look at the deadlines for your schools' "supporting information" and see if it has passed.
 
I would only send this to schools which have indicated they will accept one.
Look at the deadlines for your schools' "supporting information" and see if it has passed.
Thank you for your response.

For the schools where the deadline has not passed, is it recommended to send an email informing them of a new letter, or will sending it via AMCAS suffice?