The only specialty I'm aware of where it makes a difference is ENT (where it's required).
That said, you could do something like have 2-3 personal statements. For ex, perhaps your personal statement is very research focused, but you don't want to give that impression to your community program backups. It's reasonable to send them an alternative personal statement that doesn't have that research focus.
What I wouldn't do is have a madlib personal statement:
"Ever since I was a little boy, I wanted to live in a city like <insert city name>. A <rural/suburban/urban> location in a <hot/warm> climate..." etc.