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Hi,
What is the protocol for prolonged QT on antipsychotic medications?
I finally got a formerly severely paranoid delusional and violent male with Alzheimer's stabilized on Zyprexa 5 mg BID. However, the last EKG I ran showed Sinus Rhythym with a QTC of 504. I have put the Zyprexa on hold.
What is the protocol? Should I reduce the dose and run another EKG in a few days. Or, should I stop the Zyprexa completely and start something different? Other meds like Seroquel and Depakote have failed.
So, considering quality of life and risks vs benefits, my basic questions are,
1. At what QT interval do we reduce dose?
2. At what QT interval do we put the med on hold and for how many half lives?
3. At what QT interval do we switch to a different antipsychotic like Abilify?
4. How often should we repeat EKGs?
Thanks
What is the protocol for prolonged QT on antipsychotic medications?
I finally got a formerly severely paranoid delusional and violent male with Alzheimer's stabilized on Zyprexa 5 mg BID. However, the last EKG I ran showed Sinus Rhythym with a QTC of 504. I have put the Zyprexa on hold.
What is the protocol? Should I reduce the dose and run another EKG in a few days. Or, should I stop the Zyprexa completely and start something different? Other meds like Seroquel and Depakote have failed.
So, considering quality of life and risks vs benefits, my basic questions are,
1. At what QT interval do we reduce dose?
2. At what QT interval do we put the med on hold and for how many half lives?
3. At what QT interval do we switch to a different antipsychotic like Abilify?
4. How often should we repeat EKGs?
Thanks