Prostaglandin as a diuretic

[mybluedog]

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Since Prostaglandin causes vasodilation of the glomerulus afferent arteriole-->decreases salt/water rentention-->increases urine output

Can PGE be used as a diuretic?

I was learning NSAIDs how its contraindicated for acute HF.

 

[deleted645092]

I'm sure it could but I've never seen it. Prostaglandins have lots of systemic effects so that's probably why, since there are many more benign medications out there.

 

[Norwood-Sano]

It probably works in theory, but the more common diuretics have such a more localized and potent result, that PGE simply wouldn't be ideal.

And as @scrublyfe21 mentioned, it will have a lot more unwanted systemic effects.

Good thinking in terms of piecing everything together though!

Since Prostaglandin causes vasodilation of the glomerulus afferent arteriole-->decreases salt/water rentention-->increases urine output

Can PGE be used as a diuretic?

I was learning NSAIDs how its contraindicated for acute HF.