Step I Pth

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ctizzle13498

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Why does first aid say "PTS stimulates osteoblasts directly, but osteoclasts indirectly." If PTH increases resporption of Ca and Phos, shouldn't it only affect osteoclasts?

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ctizzle13498 said:
Why does first aid say "PTS stimulates osteoblasts directly, but osteoclasts indirectly." If PTH increases resporption of Ca and Phos, shouldn't it only affect osteoclasts?

Thanks!
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no, there is no receptor for PTH on oseoclasts, but there is one on osteoblasts, upon binding osteoblasts secrete M-CSF and RANK-L, which stimulate osteoclasts to break down bone.
 
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