PTSD advice

[nortomaso]

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Happy New Year to Everyone.

I'm going to write a review of the neurocircuitry and gene-environment interactions of PTSD as part of my senior neuroscience elective.

If anyone has any suggestions for journal articles or other resources, the advice would be greatly appreciated. 😉

-N

 

[Poety]

Do you have a VA norto? Talk to someone of the docs that treat the PTSD's exclusively and I'm sure they could give you some great articles or direct you in the right direction!


Sounds wonderful, great work!

 

[LM02]

Do you have a VA norto? Talk to someone of the docs that treat the PTSD's exclusively and I'm sure they could give you some great articles or direct you in the right direction!


Sounds wonderful, great work!

I don't have a specific citation for you (this is not my area of research). But Joseph Ledoux has written extensively on the neurocircuitry of the fear response, and I (vaguely) remember that some of his research has been discussed in terms of its applicability toward understanding PTSD. Regardless, he might be a good person to start lit searching, as it will get the ball rolling...

 

[nortomaso]

I don't have a specific citation for you (this is not my area of research). But Joseph Ledoux has written extensively on the neurocircuitry of the fear response, and I (vaguely) remember that some of his research has been discussed in terms of its applicability toward understanding PTSD. Regardless, he might be a good person to start lit searching, as it will get the ball rolling...

Thank you P and LM. I did come across citations of Ledoux in my readings and they constitute a very interesting formulation of the pathology of PTSD. Ledoux showed that certain cortical lesions were associated with the failure to extinguish conditioned fear responses. Subsequent PET studies showed that these same regions (primarily the orbitofrontal cortex) are hypoactive in PTSD patients during a fear response.

This is an exciting avenue for therapeutic interventions. Psychotherapy and TMS studies exploiting functional imaging may enable us to optimize the parameters that will strengthen the circuits in this area of the brain, rehabilitating the extinction mechanisms which enable resilient people to supress the intrusive emotional memories that torment PTSD victims.