Pyriform Sinus

[Palex80]

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For those who treat using the DAHANCA data, are you doing this also:
"All patients, except those with glottic cancers, also received the hypoxic radiosensitiser nimorazole."

We treat according to DAHANCA, but do not use nimorazole.
I presume it's based on this?

A randomized double-blind phase III study of nimorazole as a hypoxic radiosensitizer of primary radiotherapy in supraglottic larynx and pharynx carcinoma. Results of the Danish Head and Neck Cancer Study (DAHANCA) Protocol 5-85 - PubMed

Nimorazole significantly improves the effect of radiotherapeutic management of supraglottic and pharynx tumors and can be given without major side-effects.

pubmed.ncbi.nlm.nih.gov

 

[deleted1111261]

No Nim for me

Am I correct in saying they didn’t actually do BID one day but rather treated on a Saturday or Sunday?

 

[TheWallnerus]

No Nim for me

Am I correct in saying they didn’t actually do BID one day but rather treated on a Saturday or Sunday?

Yes and why I called bid once a week “DAHANCA cheat”

I will presume the DAHANCA “users” in America don’t treat Saturdays?

CHART (continuous hyperfractionated accelerated radiotherapy) for NSCLC in the UK treated three times a day. And on Saturday and Sunday. It caused therapist strikes and resignations. (Docs don’t have to be present for RT in the UK, so they were fine with CHART.)

 

[temujim]

Yes and why I called bid once a week “DAHANCA cheat”

I will presume the DAHANCA “users” in America don’t treat Saturdays?

CHART (continuous hyperfractionated accelerated radiotherapy) for NSCLC in the UK treated three times a day. And on Saturday and Sunday. It caused therapist strikes and resignations. (Docs don’t have to be present for RT in the UK, so they were fine with CHART.)

IAEA repeated the trial without nimorazole -- Five versus six fractions of radiotherapy per week for squamous-cell carcinoma of the head and neck (IAEA-ACC study): a randomised, multicentre trial - PubMed

Same basic results, so don't think of yourself as a cheater.

Foresee some big centers moving to 7 days a week treatment (not meaning patients receive 7 days continuous, just the center open for treatments). Changing the paradigm away from idle linacs 2d/week = easy win for bean counters.

 

[TheWallnerus]

Foresee some big centers moving to 7 days a week treatment (not meaning patients receive 7 days continuous, just the center open for treatments). Changing the paradigm away from idle linacs 2d/week = easy win for bean counters

Makes perfect business sense. Also imagine how convenient for patients. I am sure all rad oncs will be in love with supervising linacs on weekends 🙂