Q about Progestin and Mifepristone

[fuzzywuz]

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So progestin is suppose to stop growth of endometrium. So it's used as an OCP to prevent implantation and to thicken cervical mucous.

So what's the point of Mifepristone when progestin sorta does the same thing (block progesterone)? Is it because its more potent and causes rapid apoptosis whereas progestin just halts development of endometrium?

Thanks!!

 

[m_rivera84]

Progestin = progesterone analog
Mifepristone = progesterone inhibitor

You can use mifepristone to abort the baby. It blocks progesterone, which is needed to maintain pregnancy. If you give progesterone to someone pregnant, it won't abort the baby.

progestin is to prevent pregnancy.

 

[Step1Hash]

So progestin is suppose to stop growth of endometrium. So it's used as an OCP to prevent implantation and to thicken cervical mucous.

So what's the point of Mifepristone when progestin sorta does the same thing (block progesterone)? Is it because its more potent and causes rapid apoptosis whereas progestin just halts development of endometrium?

Thanks!!

I had thought (someone correct me if i'm wrong) progestins were progestrone receptor agonists and were used in OCP only to prevent endometrial hyperplasia from just using estrogen. If anything progestin would promote implantation bc they increased the vascularity of the endometrium which the egg needs to implant. It's the constant estrogen in the OCP that prevents an estrogen surge from happening that inhibits ovulation and pregnancy.

Mifepristone inhibits progestrone receptors and this stops the vascularization of the endometrium and stops the blood supply to the egg and thats why it works.

Once again I might be wrong but that's how I understood it.

 

[Step1Hash]

From first aid:
1. Stimulation of endometrial glandular secretions
and spiral artery development
2. Maintenance of pregnancy
3. decrease myometrial excitability
4. Production of thick cervical mucus, which
inhibits sperm entry into the uterus <--- this one
5. increase body temperature
6. Inhibition of gonadotropins (LH, FSH) <--- and here

Also, they give progesterone depo provera shots to mental ******ed people at risk of being sexually abused and assaulted.

Slipped my mind. Thanks!

 

[fuzzywuz]

Thank you!