May 25, 2015
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Q. what causes basophilia occur in apoptosis?(From FA >Basic pathology>Apoptosis).Can anybody explain this.Thanks.
 

Jabbed

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Cleavage of DNA phosphate backbone. Note that basophilia here means "stains blue" rather than "increase in basophil cell count".
 
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OP
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May 25, 2015
70
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Medical Student
You exactly read my mind.I was thinking how basophils would increase when there is apoptosis. Also, pls note that when cell undergo apoptosis, deeply eosinophilic cytoplasm and basophilia both occurs. Does that mean, cytoplasm of apoptotic cell will stain red (eosinophilic) and but the cell as a whole stain blue (basophilic)?....still somewhat confusing. Can u pls clear this doubt too.thanks.
 
Aug 9, 2014
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You exactly read my mind.I was thinking how basophils would increase when there is apoptosis. Also, pls note that when cell undergo apoptosis, deeply eosinophilic cytoplasm and basophilia both occurs. Does that mean, cytoplasm of apoptotic cell will stain red (eosinophilic) and but the cell as a whole stain blue (basophilic)?....still somewhat confusing. Can u pls clear this doubt too.thanks.
Cytoplasm red (acidic lysosomal enzymes)
Nucleus blue (nuclear shrinkage/DNA condenses)

Google image search apoptosis H&E.
 
OP
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May 25, 2015
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Thanks seminoma and jabbed for your answers. Ok, I will do google image search to for the same as mentioned by u.