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Q.splenomegaly a/w thrombocytopenia...?

Discussion in 'Step I' started by sgsh, Aug 14, 2015.

  1. sgsh

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    Q. Can anybody pls explain why patient with splenomegaly have thrombocytopeina and patient with asplenia or autosplenectomy have thrombocytosis.Thanks.
     
  2. solitarius

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    Spleen stores platelets. A larger spleen can store more platelets --> less circulating --> penia.

    Without a spleen, a storage space for platelets is gone --> more circulating platelets --> thrombocytosis.
     
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  3. sgsh

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    Nice explanation.thanks solitarius.
     
  4. aspiringmd1015

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    also where does coporphrobilinogen come from in the porphyria pathway? it accumulates in AIP
     

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