Q.splenomegaly a/w thrombocytopenia...?

[sgsh]

Q. Can anybody pls explain why patient with splenomegaly have thrombocytopeina and patient with asplenia or autosplenectomy have thrombocytosis.Thanks.

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[solitarius]

Spleen stores platelets. A larger spleen can store more platelets --> less circulating --> penia.

Without a spleen, a storage space for platelets is gone --> more circulating platelets --> thrombocytosis.

 

[sgsh]

Nice explanation.thanks solitarius.

 

[aspiringmd1015]

also where does coporphrobilinogen come from in the porphyria pathway? it accumulates in AIP