Hey anyone,
What is the purpose of alkaline phosphatase once it's released by osteoblast during bone mineralization?
What is the purpose of alkaline phosphatase once it's released by osteoblast during bone mineralization?
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And an additional question I would like to pose to my peers:
In prostate cancer, are the high levels of alkaline phosphatase due to the release of prostatic alkaline phosphatase or the osteoblastic lesions from metastasis to the the bone? Or a combination of both??
I'm not completely sure about this, but since osteoblastic activity is associated with high levels of alkaline phosphatase and osteoclastic acitivity with acid phosphatase activity, I would think that bone mineralization needs an alkaline pH in order to proceed and bone resorption would need an acidic pH.
And an additional question I would like to pose to my peers:
In prostate cancer, are the high levels of alkaline phosphatase due to the release of prostatic alkaline phosphatase or the osteoblastic lesions from metastasis to the the bone? Or a combination of both??
Aren't prostatic secretions actually high in acid phosphatase, or am I drunk again? The majority of alkaline phosphatase is found in the bone and liver, where as mentioned above, it "catalyzes hydrolysis of organic phosphate esters at alkaline pH".
My understanding was that the increase in alk phos in prostate cancer mets was directly due to the osteoblastic nature of the lesions.
Aren't prostatic secretions actually high in acid phosphatase, or am I drunk again? The majority of alkaline phosphatase is found in the bone and liver, where as mentioned above, it "catalyzes hydrolysis of organic phosphate esters at alkaline pH".
My understanding was that the increase in alk phos in prostate cancer mets was directly due to the osteoblastic nature of the lesions.