Question about benzos and nonbenzos

[ProteinTreasure]

Hello!
I need some clarification please regarding the administration of Diazepam and Lorazepam, their half-lives, peak concentration. For example, if a patient receives in one case Lorazepam 2mg IM, and in another case Lorazepam 2mg PO, how quickly concentration will be reached and what would be the half life? If we need to administer a non-benzodiazepine hypnotic (zolpidem, zopiclone) how much do we need to wait in either case? Thank you.

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[TexasPhysician]

PO Ativan reaches peak concentration faster than IM. If you want exact numbers, use Medscape.

 

[FlowRate]

If you just want those numbers, they're readily available in uptodate. What clinical problem are you trying to solve?

 

[ProteinTreasure]

If you just want those numbers, they're readily available in uptodate. What clinical problem are you trying to solve?

Thank you for your reply. I'd like to find out after Lorazepam 2mg IM how long do we need to wait to give a hypnotic (zopiclone, zolpidem, etc).

 

[J ROD]

I would suggest not to use the hypnotic in the first place.

 

[Shikima]

So, you're wholly reliant upon GABA to minimize anxiety and then also expect the VLPO to respond to the Z-BZD? Inconceivable! Just ask Michael Jackson....

 

[thoffen]

Since you're talking about IM Ativan use I assume you're in an inpatient setting? What risk are you really worried about with co-administration here? I don't think it would be very big, though that depends on the patient, but personally I wouldn't offer either intervention to someone I'd consider high risk much less the combination.

But that's just risk. Benefit on the other hand...