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I don’t know anything about serotonin but had a question that popped up in my head:
When the carcinoid tumor metastasizes into the liver via the portal vein from the small bowel, it bypasses the liver MAO enzymes, so serotonin doesn’t get converted into 5-HIAA to go into urine.
In carcinoid syndrome, serotonin released from the liver carcinoid tumor can go to the lungs and cause bronchospasm via the hepatic vein→ thoracic duct→ systemic blood supply, which is one of the symptoms of carcinoid syndrome.
In carcinoid heart syndrome, only the R side of the heart is affected because there are MAOs in the lung to convert serotonin to 5-HIAA, this spares fibrosis of the L heart.
If there are MAOs to begin with in the lung, how come carcinoid syndrome presents with bronchospasm/affects the lungs? Again, I don’t know anything about serotonin, so that probably doesn’t directly cause the bronchospasm?
When the carcinoid tumor metastasizes into the liver via the portal vein from the small bowel, it bypasses the liver MAO enzymes, so serotonin doesn’t get converted into 5-HIAA to go into urine.
In carcinoid syndrome, serotonin released from the liver carcinoid tumor can go to the lungs and cause bronchospasm via the hepatic vein→ thoracic duct→ systemic blood supply, which is one of the symptoms of carcinoid syndrome.
In carcinoid heart syndrome, only the R side of the heart is affected because there are MAOs in the lung to convert serotonin to 5-HIAA, this spares fibrosis of the L heart.
If there are MAOs to begin with in the lung, how come carcinoid syndrome presents with bronchospasm/affects the lungs? Again, I don’t know anything about serotonin, so that probably doesn’t directly cause the bronchospasm?