Ketones with different groups bonded to the alpha carbon can have varying pKas; the more electron withdrawing one group bonded to the ketone is, the more acidic will be the alpha hydrogen on the other carbon. For example, methyl phenyl ketone has an alpha hydrogen on the methyl group with a pKa of approximately 16.5 because the phenyl group enhances the electron withdrawing capacity of the carbonyl group, which is more acidic than 2-propanol, which has a pKa of approximately 17.1.
It also depends on the base that is used; an alkoxide ion will favor the thermodynamic product, i.e., deprotonate the ethyl group of the ketone, while a strong base like LDA will favor the least sterically hindered alpha carbon (i.e., the methyl group). In that case, acetone may be more readily deprotonated than 2-butanone if a strong base like LDA is used, while 2-butanone will be more readily deprotonated if an acid like sodium methoxide is used.