Dismiss Notice
SDN members see fewer ads and full resolution images. Join our non-profit community!

Question from NBME test

Discussion in 'Step I' started by Prop, Apr 10, 2007.

Thread Status:
Not open for further replies.
  1. Prop

    Prop New Member

    Joined:
    Sep 7, 2004
    Messages:
    123
    Likes Received:
    1
    Status:
    Resident [Any Field]
    Hi,

    Could anyone please help me with this question, as I cannot figure it out.

    "4 drugs produce the same therapeutic effect by the same mechanism, but each has a unique toxicity. When used at a maximally effective dose, the drug with which of the following sets of characteristics is most likely to have the highest incidence of toxicity?"

    Median effective dose Toxic dose1/Effective dose99
    A) 0.5x 2.8
    B) 1x 2.1
    C) 5x 4.0
    D) 33x 3.0

    I know the right anwer is B, but why? I simply cannot remember how to calculate this, so please, could anyone tell me how to (ie. the equation or whatever).
     
  2. Thread continues after this sponsor message. SDN Members do not see this ad.

  3. fakin' the funk

    fakin' the funk ASA Member

    Joined:
    Aug 23, 2004
    Messages:
    2,522
    Likes Received:
    403
    Status:
    Attending Physician
    Therapeutic index is what determines likelihood of toxicity, not the absolute dose that you have to use. This question relies on you falsely assuming that the absolute dose matters. Pick the drug with the lowest TI.
     
  4. fakin' the funk

    fakin' the funk ASA Member

    Joined:
    Aug 23, 2004
    Messages:
    2,522
    Likes Received:
    403
    Status:
    Attending Physician
    P.S. it's unwise to post copyrighted NBME info on this forum
     
  5. JayneCobb

    JayneCobb big damn hero....
    Moderator Emeritus

    Joined:
    Oct 17, 2006
    Messages:
    1,443
    Likes Received:
    3
    Status:
    Fellow [Any Field]
    Please see the Sticky at the top of the page

     
Thread Status:
Not open for further replies.

Share This Page