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Question from NBME test

Discussion in 'Step I' started by Prop, Apr 10, 2007.

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  1. Prop

    Prop New Member 10+ Year Member

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    Sep 7, 2004
    East coast
    Hi,

    Could anyone please help me with this question, as I cannot figure it out.

    "4 drugs produce the same therapeutic effect by the same mechanism, but each has a unique toxicity. When used at a maximally effective dose, the drug with which of the following sets of characteristics is most likely to have the highest incidence of toxicity?"

    Median effective dose Toxic dose1/Effective dose99
    A) 0.5x 2.8
    B) 1x 2.1
    C) 5x 4.0
    D) 33x 3.0

    I know the right anwer is B, but why? I simply cannot remember how to calculate this, so please, could anyone tell me how to (ie. the equation or whatever).
     
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  3. fakin' the funk

    fakin' the funk ASA Member 10+ Year Member

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    Aug 23, 2004
    Therapeutic index is what determines likelihood of toxicity, not the absolute dose that you have to use. This question relies on you falsely assuming that the absolute dose matters. Pick the drug with the lowest TI.
     
  4. fakin' the funk

    fakin' the funk ASA Member 10+ Year Member

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    Aug 23, 2004
    P.S. it's unwise to post copyrighted NBME info on this forum
     
  5. JayneCobb

    JayneCobb big damn hero.... Moderator Emeritus 5+ Year Member

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    Oct 17, 2006
    Please see the Sticky at the top of the page

     

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