Step I question on pharmacokinetics

Started by Zzmed
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Zzmed

Full Member
10+ Year Member
FA says that with renal or liver damage, maintenance dose decreases but loading dose remains unchanged.
I get the former. As soon as CL decreases, maintenace dose decreases.
But I have a problem understanding the latter. If there is liver damage--> decreased protein production--> decreased binding to protein--> increased Vd --> increased loading dose.

Am I wrong here?
 
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