Question on reconstituting vaccines

[pharmacy7424]

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For MMR, the dose is 0.5mL.

Zoster, the dose is 0.65mL.

For both, are you supposed to reconstitute the powder with an entire vial of the sterile water?

What I don't understand is that the sterile water comes in a 0.7mL vial. The package inserts for both vaccines say to reconstitute with an entire vial of the sterile water, and then to inject the entire contents of the reconstituted product. However, this seems like the total volume would be more than 0.5mL/0.65mL, as the sterile water alone is 0.7mL.

 

[zelman]

Do they come with the same diluent? is 0.7mL the liquid volume, or vial capacity?

 

[Ackj]

I've never done MMR, but for Zostavax, yes, you use the whole amount of diluent, then inject the whole amount of diluent+dissolved vaccine. The volume isn't the important part, it's that you are giving the entire amount of vaccine.

If you have 1ml of a 1mg/ml solution, what's that? How about 0.1ml of a 10mg/ml? Or 10ml of 0.1mg/ml? Same answer for each, because your total amount of solute isn't changing.

 

[kmcled]

You want to use a volume of 0.5ml of sterile diluent. After reconstitution this would yield a volume of ~0.65ml of vaccine

 

[zelman]

You want to use a volume of 0.5ml of sterile diluent. After reconstitution this would yield a volume of ~0.65ml of vaccine

Which vaccine? Did you read the original question?