Question on something heard in PASS Physio Vid

This forum made possible through the generous support of SDN members, donors, and sponsors. Thank you.

willynillysilly

New Member
10+ Year Member
Joined
Jul 30, 2013
Messages
1
Reaction score
0
I've watched the 1st of Neuromuscular physiology and Pulmonary physiology videos. Can anybody help me understand this pattern?

The instructor lists these signs and symptoms as being common to both neuromuscular diseases (NMD) and restrictive lung diseases (RLD)- why?

These are my notes for both-
RLD:
The most common signs are dyspnea and tachypnea. The most common sx are weakness and SOB. Pts with RLD are prone to URI and UTI. The skin will look dry; the hair brittle; the nail brittle; the bone marrow, depressed. Breast size- shrunken; sperm count, decreased; PCT of the nephron shuts down 1st; nausea, diarrhea, vomiting sx of the GI; most common cause of death is heart failure which in this case is aka cor pulmonale.

NMD:
Bc the heart has complete AUTONOMICS, meaning that even if the muscle is not good, the heart will continue to beat regardless, pts do not die from NM diseases due to heart failure. The most common presenting signs of ALL NM diseases are dyspnea and tachypnea. The most common symptoms of NM diseases are SOB and weakness. The most common infections are URI and UTI. Their skin appears dry, hair/nail brittle, breast size/endometrium/endothelium atrophy, bleeding from mucosal surfaces and skin, and elevated bleeding time (not pt/ppt). Most common cause of death is respiratory failure.

I'm having difficulty understanding why the S/sx are common in both of these pathologies. Can anybody help me out? I'm wondering if it's because a decrease in ATP generation occurs in both pathologies, causing a decrease in NT release which leads to the common signs and symptoms but differing causes of death.
 
Last edited:
Both RLD and NMD will result in decreased ATP because of the respiratory complications of both. People with NMD have sever respiratory issues outside of gas exchange. As you recall one of the causes of of respiratory depression are NMD's. Decreased ability to contract the diaphragm and thoracic muscles = decreased respiratory volume= decreased o2 exchange = decreased ATP production. Both lead to the same metabolic state.
 
Top