Question regarding synthesis of steroids

[vindicate]

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Steroid hormones are produced in the Mitochondria.
The 5 steroid hormones are cholesterol (produced in cytosol) derivatives - glucocorticoids, mineralocorticoids, androgen, progesterone, and esterdoil(estrogen).


However, according to few study books, and wiki "smooth endoplasmic reticulums synthesize lipids and steroids, metabolize carbohydrates and steroids, and regulate calcium concentration, drug detoxification, and attachment of receptors on cell membrane proteins."


so, where are they synthesized? the SER or Mitochondrian? is there a difference between steroid hormones and steroids?

 

[Pennpaki]

steroids are defi synthesized in the SER. Ive never heard the mitochondria thing

 

[dentalWorks]

steroid synthesis from my very limited knowledge of it is a very nasty business to learn about especially for DAT or MCAT purposes.

From what I remember, the answer is "sorta both".... Cholesterol floating around the cytoplasm goes into the mitochondria to turn into some pre-steroid molecule first, then it comes out and goes into the endoplasmic reticulum to complete the synthesis.

I say cholesterol cause thats usually the starting material for steroid synthesis

 

[vindicate]

steroids are defi synthesized in the SER. Ive never heard the mitochondria thing

I'm citing wiki, but any book will tell you the same-

"Mitochondria play a central role in many other metabolic tasks, such as:

Regulation of the membrane potential[7]
Apoptosis-programmed cell death[35]
Calcium signaling (including calcium-evoked apoptosis)[36]
Cellular proliferation regulation[37]
Regulation of cellular metabolism[37]
Certain heme synthesis reactions[38] (see also: porphyrin)
Steroid synthesis.[30]"

and dentalworks, thanks. that makes sense.