Question related to o2 dissociation curve

[DarSh12]

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Hi ,
in Goljan review page 13 , it is stated that acidocis causes right shift of the curve

then , he said that the effect of altitude which causes respiratory " alkalosis" will lead also to right shift of the curve

i got confused , can anyone understands this paradox ?

 

[dfib slim]

Hi ,
in Goljan review page 13 , it is stated that acidocis causes right shift of the curve

then , he said that the effect of altitude which causes respiratory " alkalosis" will lead also to right shift of the curve

i got confused , can anyone understands this paradox ?

Maybe the increase in 2,3 BPG overrides the alkalosis?

 

[CodeRedDew]

Hi ,
in Goljan review page 13 , it is stated that acidocis causes right shift of the curve

then , he said that the effect of altitude which causes respiratory " alkalosis" will lead also to right shift of the curve

i got confused , can anyone understands this paradox ?

High altitude leads to an increase in 2,3-BPG -> right-shifts O2 dissociation curve

 

[DarSh12]

i really considered this explanation but how the alkalosis which increases 2-3 BPG can in other instances lead to left dissociation of the curve ??

 

[aspiringmd1015]

alkalosis stimulates PFK-1 i believe, so increased 2,3 bpg balancing the shift