another contested qbank question. renal...again.
Q: a certain substance that is freely filtered and secreted, is being maximally secreted. As the plasma concentration increases, the renal clearance:
-decreases and approaches that of inulin
-increases and approaches that of inulin
-increases to the renal plasma flow
-will remain the same
the correct answer according to qbank is the first one. i have a problem with this. i agree that the substance has the same slope as inulin at saturated levels, which is of neither being secreted or reabsorbed. however, i don't believe that the clearance will decrease. if you increase the plasma concentration of the substance, you do saturate the secretion transporters, but the increased concentration is still going to increase the urinary concentration of that substance, and clearance = U V/ P
am i missing something here? i understand the idea of saturation of the secretion proteins, but nevertheless, even though the kinetics of clearance of this substance at saturated concentrations is the same as inulin, it still has the added clearance due to the secretion proteins.
look at pg. 173 brs physio. the excreted line of PAH has the same SLOPE as the filtered (inulin) line, but nevertheless, the PAH line is still HIGHER. since there is more substance being excreted at every point compared to inulin, the clearance must always be higher.