Quinolone in UTI

Started by ZpackSux
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so my final question is how does this idea that avelox can't be used for a UTI get started and how is it still going?

This question is even better than your previous answer.

Why don't you try to answer it?
 
Why do you think Januvia causes an increased rate of upper respiratory tract infections?

Because it inhibits GLP (glucagon like peptide) in which can lead to inflammation of the respiratory tract leading to allergic and cold like symptoms including post nasal drip which can paralyze the cillia like action of the respiratory tract which results in colonization of infecting bacteria or virus to cause respiratory infection.
 
Because it inhibits GLP (glucagon like peptide) in which can lead to inflammation of the respiratory tract leading to allergic and cold like symptoms including post nasal drip which can paralyze the cillia like action of the respiratory tract which results in colonization of infecting bacteria or virus to cause respiratory infection.

Nice!!!(is that right?)
 
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That ain't what I'm looking for...
Glucagon like peptide...man...not even barking up the right tree.

It inhibits DPP-4....which in turn inhibits the inactivation of GLP and GIP. You got the end results flip flopped.

Bark up the DPP-4 tree...

and maybe I should rephrase...what about the inhibition of DPP-4 makes you think there may be an increase in infection...
 
That ain't what I'm looking for...
Glucagon like peptide...man...not even barking up the right tree.

It inhibits DPP-4....which in turn inhibits the inactivation of GLP and GIP. You got the end results flip flopped.

Bark up the DPP-4 tree...

and maybe I should rephrase...what about the inhibition of DPP-4 makes you think there may be an increase in infection...

DiPepeptidyl Peptidase 4 also known as the CD 26 is a T cell stimulator in which when inhibited, can affect the immune response of T-cell, B-Cell, and Natural Killer Cells. Obviously this can trigger an increase in infection coupled with GLP inhibition which results in inflammation and allergy like symptoms.

But some studies suggest the immune activating component of DPP-4 is not affected by DPP4 inhibitor..
 
DipePeptidyl Peptidase 4 also known as the CD 26 is a T cell stimulator in which when inhibited, can affect the immune response of T-cell, B-Cell, and Natural Killer Cells. Obviously this can trigger an increase in infection coupled with GLP inhibition which results in inflammation and allergy like symptoms.

But some studies suggest the immune activating component of DPP-4 is not affected by DPP4 inhibitor..

Blingo.

I say "whatever" to those studies. Increased incidence of URI is intriguing enough. I would definitely think twice before I give it to an HIV or cancer chemo receiving patient..

It's not as blatantly bad as Tysabri, though...which interestingly claims zero cases of PML since reintroduction...hmmm...