PossibleEMapplicant
Full Member
- Joined
- Jan 29, 2019
- Messages
- 45
- Reaction score
- 3
- Points
- 801
Just a lost soul of a 3rd year medical student here. Are their any Rad-Onc programs that are DO friendly? And to all you working and lurking the forums, do any of you wish you went into heme/onc?
Just a lost soul of a 3rd year medical student here. Are their any Rad-Onc programs that are DO friendly? And to all you working and lurking the forums, do any of you wish you went into heme/onc?
Just make sure you know what you're getting into. As an example...And to all you working and lurking the forums, do any of you wish you went into heme/onc?
Long time lurker. This is my situation and obviously not the norm, so take this as you will. I am 1 month away from graduation with no job so I will be doing locums. Failed the biology boards so I have been studying frantically over the last 6 months for something that I will never use in my life. Spouse filed for divorce 3 weeks ago (likely unrelated to my career choice...but not entirely). Do I wish I did Heme/Onc? Selling hotdogs in LA looks pretty awesome right now, so I can't really give you an unbiased answer.
Just make sure you know what you're getting into. As an example...
In 2015, a randomized trial of about 500 patients appeared testing consolidation RT in extensive stage small cell. The trial was positive:
2y OS 13% vs 3%, p=0.004. Progression free survival @6mos 24% vs 7%, p=0.001.
Conclusion: "Thoracic radiotherapy in addition to prophylactic cranial irradiation should be considered for all patients with ES-SCLC who respond to chemotherapy."
Last year, a randomized trial (IMpower133) of about 400 patients appeared testing atezolizumab (Tecentriq) in extensive stage small cell. The trial was positive:
Median OS 12 mos vs 10 mos, p=0.007. Median progression free survival 5 mos vs 4 mos, p=0.02.
Conclusion: "The addition of atezolizumab to chemotherapy in the first-line treatment of extensive-stage small-cell lung cancer resulted in significantly longer overall survival and progression-free survival than chemotherapy alone."
Just look at the conclusions and their wording to understand the first hint of the problem. Today, thoracic RT in ES-SCLC is not that commonly practiced; mostly because the med oncs don't refer them! Even if I were to urge for it on this forum, amongst radiation oncologists, I would receive lackluster support. "That is not really the standard." "Be careful, there are drawbacks." It is not a category 1 NCCN recommendation. It is simply to be "considered."
But almost immediately upon publication of IMPower 133, Tecentriq became standard of care in ES-SCLC. (And this single drug will make more for its company in one year than is spent upon the entirety of radiation oncology for all treatments in one year.) It's a category 1 now about 4 months after publication and was just FDA approved last month!
Like I said. Just be aware. "Woke." And then stick with your choice.
Do I practice consolidation thoracic RT for ED-SCLC-patients? I do. .
"Even if I were to urge for it on this forum, amongst radiation oncologists, I would receive lackluster support." I don't need to make any points if y'all make 'em for me.Well... That's not entirely accurate scarbrtj...
CREST was actually NEGATIVE for its primary endpoint, which was 1-year-OS.
At 1 year OS was 33% for CT+RT vs. 25% vor CT alone and that was not a statistical significant difference
The 2-year endpoint is nice, but it was not the endpoint of the trial.
And the observation at 2 years was based on 19 (!) evaluable patients left. 14 with CT+RT and 5 with CT only.
🙂
Do I practice consolidation thoracic RT for ED-SCLC-patients? I do. Mostly on
a) "favorable" prognosis patients (by common sense) which to me means no extensive liver disease at baseline and
b) patients with substantial residual disease in the thorax after CT. It seems that they may profit a bit more according to the (underpowered) subgroup analysis of the CREST trial.
You can only practice appropriate medicine on the patients who were appropriately referred to you. Sometimes, I'll get LS referrals directly from pulm, but less so in ES since it's chemo upfront. So essentially you're hoping MO understands the benefit in ES pts as well as you do 😉
MOs that are more recently trained will send me those pts for evaluation, but old school ones won't in my experience
Wallner, DOThis sucks man, when the chairs and PDs that come here to laugh at SDN They should keep an open mind about what they have sown. They’ll follow Wallner to the depths apparently especially kachnic, these stories are the casualties of that.
Neglected to mention above, but the Tecentriq data and trial, and what with Tecentriq being now the "true standard" (above thoracic XRT), radiation oncologists should be out of the front line ES-SCLC business anyways. So it's all water under bridge. (And the Tecentriq trialists should be castigated mightily for not making the control arm chemo/XRT; don't hold breath for rad oncs to do this.)My experience as well. The new surgeons, med oncs are more willing to discuss treatment options vs. practicing without any input. The old school ones just give the chemo, do surgery and only refer to me when there are no other available options left. Hopefully in time, there will be a change in referral patterns so there may be a silver lining once these docs retire.
Long time lurker. This is my situation and obviously not the norm, so take this as you will. I am 1 month away from graduation with no job so I will be doing locums. Failed the biology boards so I have been studying frantically over the last 6 months for something that I will never use in my life. Spouse filed for divorce 3 weeks ago (likely unrelated to my career choice...but not entirely). Do I wish I did Heme/Onc? Selling hotdogs in LA looks pretty awesome right now, so I can't really give you an unbiased answer.
"Even if I were to urge for it on this forum, amongst radiation oncologists, I would receive lackluster support." I don't need to make any points if y'all make 'em for me.
"The 2-year endpoint [for thoracic RT] is nice, but it was not the endpoint of the trial. And the observation at 2 years was based on 19 (!) evaluable patients left. 14 with CT+RT and 5 with CT only." And in IMpower133 we don't even have data at 2 years. Heck at 18 months, there are about 8 (!!!) patients followed out that long thus far.
"What if they had a priori set a 2y OS endpoint in the thoracic RT ES-SCLC trial?"
"But they didn't."
"But what if they had done that before the trial started?"
"Well then they would have met their endpoint I guess. But they didn't set it that way, and didn't meet what they set. Thus, the results take on an entirely different flavor because of this even though the arbitrary pre-trial endpoint setting, which totally vary from trial to trial, wouldn't have changed the raw results one iota."
Number of rad oncs poo-pooing (or damning by faint praise) thoracic RT for ES-SCLC, >0. Number of med oncs poo-pooing Tecentriq, = 0.
EDIT:
(Theoretically those two lines, the cyan and the light grey, are the same patient population subsets. Theoretically. So even getting considered for immunotherapy but not receiving it improves survival dramatically! This immunotx is powerful stuff.)
View attachment 260875
"Even if I were to urge for it on this forum, amongst radiation oncologists, I would receive lackluster support." I don't need to make any points if y'all make 'em for me.
"The 2-year endpoint [for thoracic RT] is nice, but it was not the endpoint of the trial. And the observation at 2 years was based on 19 (!) evaluable patients left. 14 with CT+RT and 5 with CT only." And in IMpower133 we don't even have data at 2 years. Heck at 18 months, there are about 8 (!!!) patients followed out that long thus far.
"What if they had a priori set a 2y OS endpoint in the thoracic RT ES-SCLC trial?"
"But they didn't."
"But what if they had done that before the trial started?"
"Well then they would have met their endpoint I guess. But they didn't set it that way, and didn't meet what they set. Thus, the results take on an entirely different flavor because of this even though the arbitrary pre-trial endpoint setting, which totally vary from trial to trial, wouldn't have changed the raw results one iota."
Number of rad oncs poo-pooing (or damning by faint praise) thoracic RT for ES-SCLC, >0. Number of med oncs poo-pooing Tecentriq, = 0.
EDIT:
(Theoretically those two lines, the cyan and the light grey, are the same patient population subsets. Theoretically. So even getting considered for immunotherapy but not receiving it improves survival dramatically! This immunotx is powerful stuff.)
View attachment 260875
I know we've argued about statistics in other threads, but just want you to know that I whole heartedly agree with you on this. Don't give 2 craps on the primary endpoint not being positive if it gives us a clinically relevant endpoint that is improved with RT.
However, because the trial is officialy a 'negative' trial I'm not surprised it wasn't included in the control arm. I feel like we see a decent amount of Thoracic consolidation for ES-SCLC but obviously I don't know the denominator. Would prefer it for the 'more favorable' ES-SCLC prognosis patients, personally.
And as Paul Harvey would say...I stand by what I said.
CREST was designed to detect a 10% survival benefit at 1 year. The investigators assumed a 27% OS at 1 year with standard of care and 37% with the addition to RT (10% benefit). Were they to achieve that, the trial would have been positive. They didn't. Survival was 28% without and 33% with RT. They predicted 1 year survival with standard of care pretty accurate (congratulations for that), but the benefit with RT was smaller than assumed.
The difference at 2-years survival is based on data coming from 19 patients.
CREST could not have been designed with a 2-years-endpoint, because noone knows what survival will look at 2 years, it's too hard to predict since so few patients live that long (and crest proved that too: these 19 patients represent 4% of the entire study population; the other 96% were either dead or censored by then).
The Tecentriq trial had another primary endpoint and reached it with a positive result. That's it.
And of course big pharma has the money to fund big trials. But we cannot measure the results our trials with other levels of scientific evidence, simply because we don't have the money. That's life.
Fair point, but it provided a great example of the mentality present that is to the detriment of our fieldIf you want to work with colleagues that debate about thoracic radiation in small cell lung cancer when the question is about DO friendly residency programs go for it.
And as Paul Harvey would say...
In one trial, thoracic RT improved survival (p=0.04).
In another trial, it also improved survival (p=0.06).
And in another trial, thoracic RT harmed survival (p=0.21).
Thank Minerva for Tecentriq.
For the benefit of the OP, our specialty's speciality: reductio ad absurdum.Fair point, but it provided a great example of the mentality present that is to the detriment of our field
If you want to work with colleagues that debate about thoracic radiation in small cell lung cancer when the question is about DO friendly residency programs go for it.
off-hand, I know wayne state, FCCC, Jefferson, Cincinnati, Cleveland Clinic - I'm sure others.. although I'd say Midwest overall is more DO-friendly than the coasts
Soooooo... A trial on stage IV/metastatic RCC between systemic therapy combinations where radiation has never played a major role... means radiation has no future in oncology. Got it
Soooooo... A trial on stage IV/metastatic RCC between systemic therapy combinations where radiation has never played a major role... means radiation has no future in oncology. Got it
200 *new* jobs a year in rad onc??? What were people thinking.But, are there 200 quality new full-time positions per year in rad onc? My answer: probably not now, and certainly not for long.
It's not unlike the mafia's business model. What does that make the modern rad onc? Davey Scatino?The bargaining power of being a specialist physician has been severely eroded. But it's not as if radiation oncology reimbursements are being slashed--admins and practice owners are just more than happy to take that extra money off your hands for your work, pay you less, and negotiate downwards to the next desperate new grad if you complain.
Dude it’s a free for all for interested Med students MD or DO. RO isn’t competitive anymore. DOs have a legit shot at good programs. PDs used to turn their noses up at people with DOs and sub 240 step 1 scores are now basically looking for warm bodies to do their work.
They don’t care if you didn’t learn anything or if you ever pass your boards. Just that you decided to spend four years of doing consults and drawing circles so they can press plan approved and suck up more CMS money.
If DOs now "stand a shot" in radiation oncology, maybe that isn't such a bad thing after all. MCATs and college grades don't always translate into clinical and emotional competence... in fact, it wouldn't surprise me if the opposite is true in some cases. The hardest working residents are those who are grateful for the opportunity, not those who feel entitled to have it easy because they cracked 250 on step I. I worked with some amazing DOs and FMGs during my internship and would feel no apprehension about referring my patients to them over a top ten grad, AOA+/step 1 270 etc... Elitism is its own punishment. Maybe now we will be rewarded by getting work with some talented, invested, compassionate residents with different perspectives and experiences who fought tooth and nail for a spot they never dreamed they could get.
This is 100% my PD and the tenured folks at my program.
I do whole heartedly agree that I would much rather have somebody who was interested in Rad Onc during medical school and is a DO and/or doesn't have the strongest stats (ideally no failures on the board exams though) rather than somebody who tried to match derm/ortho/ophtho/other competitive specialty and fell into rad onc as a back-up.
But the reality is that the 'competitiveness' of rad onc likely just took a nose dive. I imagine there will be minimal unfilled spots next year as it becomes known to DOs and IMGs that this field is no longer competitive and programs will be forced to interview and rank them to ensure that they match any warm body to their program.
The latest is leadership feels the unfilled spots are a one time blip. They’re about to really wake up next year, 27 unfilled is nothing. There simply are not 200 jobs a year to fill in the country, not even 150. This year 27 unfilled, next year 50. So feel free to apply DO’s, this is among the easiest fields in medicine to get into now
If this is true, won't students initially turned away form the competitiveness (eg. DOs, lower step scores etc) enter the field and take up those unfilled spots? Regardless of job opportunities, if that happens, it'll actually look like a one time blip.
If this is true, won't students initially turned away form the competitiveness (eg. DOs, lower step scores etc) enter the field and take up those unfilled spots? Regardless of job opportunities, if that happens, it'll actually look like a one time blip.
Not aware of a new google doc, and based on the factually incorrect IJROBP article calling it the 'SDN spreadsheet' when it had bad, bad things in it that SDN does not agree with but was outside the scope of our moderation for the past 2 years, we will not be stickying the thread that links to it or 'promoting' it in anyway on SDN.
Maybe whoever creates it can post it on ROHub and academicians can call it 'the ROHub spreadsheet' in future publications.
Can we encourage applicants to go back to the system we had of interview impressions being a forum thread? The “reviews” of programs on the spreadsheet are so easily manipulated that I think it’s unfair to applicants and programs. When we had threads, the reviews were more systematic and comprehensive. Now it’s maybe a sentence or two summarizing an entire program. Also, 95% of the “data” on the spreadsheet is completely meaningless