4th year applicant here, Accepted at WVSOM and ECU(waitlisted though, grrrr! ).
Nothing is really different except at the schools you interview at each year they run out of people to interview you and they can't ask you the same dumb questions like "Where do you see yourself in ten years?" because they already know the answers. 🙂
Heck, I think I know half of the docs at ECU now!
Never give up, I say. I took my MCAT 3 times ( computer science major, had a low bio score cause I took the bare minimum for classes, retaught myself biology in my spare time, got it up)
My suggestion is goto exit interviews to pinpoint your application issues then work on em and do it. 🙂
-Richie