Step I Renal Confusion

[aspiringmd1015]

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How does AT2 promote contraction alkalosis(FA pg 532) bc youre reabsorbing water, and hc03, but its not a new hc03, H+ thats being secreted via the H/Na exchanger is is combing w/a filtered bicarb

also w/PTH, does it work directly by p04'ing the luminal Ca+ channel, or on the Na/Ca2+ transorter on the basolateral membrane. FA and Kaplan have different things.

 

[pathologyDO]

How does AT2 promote contraction alkalosis(FA pg 532) bc youre reabsorbing water, and hc03, but its not a new hc03, H+ thats being secreted via the H/Na exchanger is is combing w/a filtered bicarb

also w/PTH, does it work directly by p04'ing the luminal Ca+ channel, or on the Na/Ca2+ transorter on the basolateral membrane. FA and Kaplan have different things.

That HCO3- would just be excreted if the H+ didn't combine with it to form CO2 which is reabsorbed, so it is extra HCO3- (as CO2) being reabsorbed that otherwise wouldn't be.

As for the PTH it works in the PCT to decrease PO4 2- reabsorption, and inrease reabsorption of Ca2+ in DCT via the Ca2+/Na+ exchanger. When in doubt go with FA

 

[aspiringmd1015]

i thought the bicarb added in the circulation isnt a "new bicarb" unless by preventing bicarb excretion in the urine is the exact mechanism of contraction alkalosis rather than adding to the circulation