Renal failure

[Hemichordate]

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What is the mechanism by which renal failure causes hyperkalemia, metabolic acidosis, and increased triglycerides?

 

[loveoforganic2]

What is the mechanism by which renal failure causes hyperkalemia, metabolic acidosis, and increased triglycerides?

HyperK - decreased excretion via decreased GFR and impaired tubular function
Acidosis - failure of bicarb production/reabsorption and failure of excretion of organic acids
HyperTG - Weird stuff. Don't think it's testable, other than maybe the fact that it occurs (although I hadn't been aware of that til your post). http://www.nature.com/ki/journal/v63/n84s/full/4493785a.html If you really want to know

 

[Hemichordate]

Thank you sir/madam.

 

[dotdotdot]

On that note, is it true that renal failure can cause either hypernatremia (from failure to excrete) or hyponatremia (from failure to reabsorb)? If so, what determines which occurs?

 

[loveoforganic2]

On that note, is it true that renal failure can cause either hypernatremia (from failure to excrete) or hyponatremia (from failure to reabsorb)? If so, what determines which occurs?

My "guiding paradigm" for how I think about renal failure is, whatever normally happens in the kidneys, the opposite happens. So that would lead me to say hyponatremia. With that said, the kidneys are complex as hell (nephrologists have a smart rep for a reason), so I would be 0% surprised if hypernatremia is a possible outcome (I would expect it, intuitively, as a possibility in very late dz or acutely in bilateral ureteral obstruction due to severely decreased GFR)