renal oxygen consumption

[stronghold]

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When renal oxygen consumption is the highest? high GFR? high RBF? or high FF? and why?

 

[Trogghunter]

Filtration is pressure dependent mostly, so states of increased renal demand/blood flow require more O2, but blood volume/perfusion is the key for the kidney. You get ARF when you have low blood flow, not when youre hypoxemic. The kidney can't be in such an O2 consuming state that other organs (brain) wouldn't fail first, and its cells probably don't generate so much ATP to really be at risk of hypoxemic hypoxia.

 

[stronghold]

So you mean oxygen consumption will be high when FF is high?

 

[Myxedema]

Renal oxygen consumption is highest when the kidney is actively working as it reabsorbs Na+. If you think about the formula that filtered load = GFR x plasma concentration, then it is possible to see how GFR and renal oxygen consumption is linked: If you increase GFR, you increase the filtered load, which the kidney works even more actively to reabsorb back, which increases renal oxygen consumption.