Repliosome?

[csx]

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Anyone know what this is and how it differs from Helicase? Their functions sound the same to me -__-

 

[sillyjoe]

Anyone know what this is and how it differs from Helicase? Their functions sound the same to me -__-

For the MCAT, the polymerase plus all of the accessory proteins like the helicase that come together to form a complex is known as the replisome.

 

[orangetea]

So it's easier to think about the replisome as like a big tool box which carries certain tools such has helicase, DNA Pol1 , etc.

It is essentially a complex that carries various proteins including helicase.

 

[sillyjoe]

So it's easier to think about the replisome as like a big tool box which carries certain tools such has helicase, DNA Pol1 , etc.

It is essentially a complex that carries various proteins including helicase.

View attachment 183290

Think of it like this: The polymerase, gyrase, helicase, and other various initiation factors etc. do NOT act in isolation of each other. Rather, they come together and complex in what is known as a replisome.

 

[DrknoSDN]

"The replisome is composed of a number of proteins including helicase, RFC, PCNA, gyrase/topoisomerase,SSB/RPA, primase, DNA polymerase I, RNAse H, and ligase."
The replisome is the combination of all the smaller functional subunits.


http://en.wikipedia.org/wiki/Replisome (Paragraph 2)