What university do you attend? I go to UCLA by the way. Biochemistry is considered a physical science major so I have to take the physical science series for chemistry and calculus, which is why my GPA is so messed up. But anyway, we have to take up to calculus 3, which is multivariable. And yes, you absolutely need calculus 3 to take physical chemistry. I don't even know how it's possible to do p chem w/o understanding total differential and partial derivatives. Maybe your professor will take a few weeks to go over that stuff. If you're a chem major at my school, you take math, physics and p chem until you die, and I don't believe you have to take any bio classes as a chem major. In high school, I thought chem was the easiest science...damn I was so naive. I have a whole new level of respect for chemist. They are genius. P chem is so hard and over my head...so depressing. I feel like I'm failing this quarter.