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Apparent Effects of Opioid Use on Neural Responses to Reward in Chronic Pain - Scientific Reports
Neural responses to incentives are altered in chronic pain and by opioid use. To understand how opioid use modulates the neural response to reward/value in chronic pain, we compared brain functional magnetic resonance imaging (fMRI) responses to a monetary incentive delay (MID) task in patients...
www.nature.com
Is this setting the stage for a medical reversal in the treatment of fibromyalgia?? Please check your Semmelweis Reflex before responding...
"Together, these preliminary data suggest that neural responses to monetary incentives differ between individuals with fibromyalgia who are not taking versus taking opioid medications. The relatively “normalized” MPFC response to anticipated rewards and non-punishments in individuals with fibromyalgia taking opioids may relate to opioids’ ability to positively influence hedonic experience in chronic pain (i.e., or the belief of individuals with fibromyalgia that they benefit from opioid use), despite other potentially negative influences of long-term opioid use on chronic pain. Based on the current debate on the utility of opioids for long-term management of chronic pain, these findings may be controversial. We therefore encourage readers not to extrapolate these findings to suggest that opioids may, or may not, be of value in the treatment of fibromyalgia."
