RTA type 2

[Step1Hash]

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Anyone know why RTA type 2 is associated with hypophosphatemic rickets?

 

[sgod34]

Yes, because in RTA 2 (prox tubule reabosorption failure) you get phosphate wasting, which leads to decreased PTH stimulation due to low PO4 levels. The decreased PTH activity also decreases Vit D activation and Ca, which than leads to decreased bone mineralization and Rickets/Osteomalacia.

 

[Step1Hash]

Yes, because in RTA 2 (prox tubule reabosorption failure) you get phosphate wasting, which leads to decreased PTH stimulation due to low PO4 levels. The decreased PTH activity also decreases Vit D activation and Ca, which than leads to decreased bone mineralization and Rickets/Osteomalacia.

thanks! I don't know why I didn't think of that myself.

 

[mikey014]

i was actually just memorizing that association. but your explanation made a lot more sense. THANKS! epiphany! 👍