s3 and s4

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trgf

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What is the difference between s3 and s4? I know that s4 occurs in ventricular failure, yet physiologically, what happens to cause the sounds in both of them? Aren't both effected by atrial blood splashing against ventricular walls?

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s3 is thought to be caused by the chordae tendinae tensing. S4 is caused the extra atrial "kick" near the end of diastole because of a hypertrophic Left ventricle that produces a crap ton of turbulence
 
Not sure about the S3 being the chordae tensing, but that seems plausible since all the blood rushes into a dilated ventricle causing some sort of "rebound" contraction.

Anyways the S3 as I learned it is an early diastolic sound of blood rushing into a dilated ventricle with increased compliance or with increased volume of blood(due to something like mitra regurg. or tricuspid regurg). The blood passively spills into this chamber with lots of fluid/volume.

S4 is late diastole, and thats when the atria contracts. It can either be due to a rebound (e.g. in a concentrically hypertrophic heart) against the muscle of the heart or due to fluid overload, because atria contracting against excess fluid could also cause a turbulent sound.

Therefore, in a concentrically hypertrophic heart you would definitely hear an S4, but probably not an S3 since there really isn't fluid overload in the ventricle.

In mitral regurg, you would hear an S3, and maybe an S4 if it is an early mitral regurg.


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Another way to put it, kind of simplifies it in my mind:

I imagine S3 to be like a waterfall...all that fluid hitting more fluid passively.

I imagine S4 to be like hitting a drum. The atria pushes that blood into the wall of the ventricle hitting either muscle or more blood causing a sound.
 
S3 = blood is hitting an under-ejected ventricle so it's like a rock hitting water (but the rock is also made of water). Since it's a marker of volume overload it's also a marker of congestive heart failure (if pathologic, under a certain age i believe it's physiologic).

S4 = atrial kick against a stiff left ventricle, associated with either fluid overload or a thickened left ventricle (concentric). It can be a marker of heart failure or chronic aortic stenosis (the atrial kick is needed in order to maintain blood pressure since you have hypotension with severe aortic stenosis).
 
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