I'm doing an EM residency right now. I was the only one in my class who didn't get their first choice (I got #3 on my rank list).
Being an FMG does make it harder to get interviews, but once you've got the interview, I don't think it changes much. The match software allows PDs to filter out FMGs applications, so I was rejected very early by some of the snootier places.
US grads with my scores got twice as many interviews as I did, but hey, I started turning down interviews after the first 10.
If you're sure you want to be in a really prestigious residency, you might consider Sackler twice. However, I feel that the education and experience more than made up for it.
Pros
#1 - great rotation schedule - the WORST schedule I had as a med student was 8-4 M-F. U.S. med students frequently do 6 days a week, 12 hours a day, with q3-5 call.
#2 - taught by attendings, not residents (this is a big deal, trust me) = much better education
#3 - being in Israel
#4 - lots of vacations, and only 4-6 hours by plane from Europe
Cons
#1 - Harder to get competative residency
#2 - being in Israel