Say Goodbye to Bextra
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bbmuffin said:
You beat me to it!
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As a patient, I'm not happy about this. I found it to be a very good non-narcotic pain killer when no other non-narcotics did me any good. 🙁
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ZpackSux said:
Definitely. But I'm specifically talking about pain from endometriosis here. I took large doses (significantly over the labelling recommendations) of a variety of OTC NSAIDs with no relief at all. Celebrex didn't help either, but 40 mg of Bextra q D made it bearable. The only other things that helped were narcotics, which I didn't want to take for any length of time.
I've had surgery since then & no longer take Bextra, but I have a few samples stored up *just in case*... now I'll be scrounging to see if I can get more before it all really disappears.
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DrMom said:
Voltaren/Cataflam or Lodine are good options if you get in a bind
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thanks baggywrinkle.
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DrMom said:
"Definitely" that COXII provides a superior analgesic effect? If Celebrex didn't work for you, then it's not the COXII that works for you..it's just Bextra that works for you.
For Dysmenorrhea.. Bextra is recommended 20mg Bid.. or 40mg Daily would work too I guess. We have substituted Bextra 10mg with Celebrex 100mg. At 40mg of Bextra.. you would had to have tried 400mg of Celebrex for equal efficacy?
40mg Bextra is a big dose. Probably equivalent to 800mg Ibuprofen TID..
I have not seen a clinical trial where COX II provided superior analgesic efficacy over other NSAIDS of so called equivalent dosing...if there is such a thing. Then again, who can argue with the individual variation of pharmacotherapy response.
I've always felt that COXII were a scam... advertised and marketed as NSAIDs with reduced GI ADR. BS.
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DrMom said:
Maybe not, the entire class of drugs now is black boxed. With the climate
we have today all the NSAIDs may be yanked. That's just sad...
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jdpharmd? said:
It's a pharmaceutical co game at its' best. Merck tried to capture the market by heavily discouting Vioxx at 10 cents a tab to all hospitals who were willing to dispense nothing but Vioxx. Then Pfizer with Celebrex bought out Bextra to capture 70 percent of the market. With Vioxx being pulled...and then back on the market.. no one hardly uses Vioxx anymore.
There are and will be class action lawsuits against Merck and Pfizer.
See you Later COX IIs.... you've ripped off enough Americans.
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ZpackSux said:
I'm not sure why Celebrex didn't work, but it didn't. I was taking 200 of it BID. I took ibuprofen at a high dose like that (12-16 200 mg pills/day) & it killed my stomach with minimal pain benefit. Who knows why Bextra worked for me when the others didn't.
Anyways, I had just butted into this thread because I'm very unhappy that this drug is gone. I scoured my stash & only have 4 1/2 days worth on hand.
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Is this a class 1 or 2 recall? The letter said 2, but the form we were sent said 1. 😕
Celebrex 400 mg qd does not generally provide additional relief vs 200mg qd. That's why the 400mg (green!) capsules are rarely stocked anywhere. I guess if one was an ultrametabolizer for CYP2C9, they might see a difference in efficacy.
COX II inhibitors aren't inherently superior in terms of analgesia vs other NSAIDs.
Pharmacies will have pulled the drug from their shelves and be shipping it back to their distributors. Your best bet for getting ahold of any Bextra at this point in time is to see if someone you know has samples hanging around in their office.
Celebrex 400 mg qd does not generally provide additional relief vs 200mg qd. That's why the 400mg (green!) capsules are rarely stocked anywhere. I guess if one was an ultrametabolizer for CYP2C9, they might see a difference in efficacy.
COX II inhibitors aren't inherently superior in terms of analgesia vs other NSAIDs.
Pharmacies will have pulled the drug from their shelves and be shipping it back to their distributors. Your best bet for getting ahold of any Bextra at this point in time is to see if someone you know has samples hanging around in their office.
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ZpackSux said:
Umm, the 90's called and they'd like that broad brush you've been painting with back.
You're faulting the DRUGS for ripping off Americans?
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We either blame drugs or dentists for everything, Gavin. You're getting off easy this time. Don't knock it. 😛
The idea of the rest of the NSAIDs being withdrawn is kind of farfetched. COX2 exclusive inhibitors are supposedly associated with a greater incidence of because they lack the mitigatory cardioprotective effects that other NSAIDs are able to confer through concurrent COX1 inhibition.
Since when is Vioxx back on the market? Are you getting free bottles sent along with your monthly shipment of moonshine?ZpackSux said:
The idea of the rest of the NSAIDs being withdrawn is kind of farfetched. COX2 exclusive inhibitors are supposedly associated with a greater incidence of because they lack the mitigatory cardioprotective effects that other NSAIDs are able to confer through concurrent COX1 inhibition.
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I wouldn't say Cox II's are THAT bad. They were just overprescribed via the direct to consumer marketing and hence their requiring prior authorization. My mom and aunt prefer ibuprofen but those NSAIDs upset their stomachs and only Celebrex seemed to work for them without upsetting their stomach. They had to jump through a few hoops before insurance would pay for them, but it's good to occasionally use when their arthritis pain gets unbearable.
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If you look at the risks for COX2's vs say, psych meds, it's pretty obvious that consumers are expected to put up with a large risk for some treatments. If someone is in crippling ostroarthritic pain, frankly, the benefits almost certainly outweigh the benefits. The regular NSAIDs are just too hard on the stomach for long term toleration, especially in the elderly. I would be sad to see the entire class go, because of a fear of lawsuits and adverse public perception. The people who really need the drugs are sad to see them go, despite the risks. It's too bad that these patients are losing the opportunity to choose quality of life over a small risk of decreasing its duration.
I do agree that DTCA resulted in over prescribing. Perhaps if this were not the case, the drugs would still be on the market, as their risk:benefit ratio in useage would presumeably be more favorable if prescribed only when truly indicated.
I do agree that DTCA resulted in over prescribing. Perhaps if this were not the case, the drugs would still be on the market, as their risk:benefit ratio in useage would presumeably be more favorable if prescribed only when truly indicated.
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bananaface said:We either blame drugs or dentists for everything, Gavin. You're getting off easy this time. Don't knock it. 😛 Since when is Vioxx back on the market? Are you getting free bottles sent along with your monthly shipment of moonshine?
The idea of the rest of the NSAIDs being withdrawn is kind of farfetched. COX2 exclusive inhibitors are supposedly associated with a greater incidence of because they lack the mitigatory cardioprotective effects that other NSAIDs are able to confer through concurrent COX1 inhibition.
Ok.. I had a momentary brain aneurysm.. I remember Merck purshing to bring back Vioxx..
http://www.msnbc.msn.com/id/6992099/
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Stretching your brain too much can be a bad thing. 😉ZpackSux said:
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bananaface said:
Got a month's supply of samples today 👍 I'm guessing that's the last I'll find, though.
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Sweet! 😀DrMom said:
L
lord_helmet
Well, I believe that one reason for bextra and celebrex getting the axe is because Doctors perscribe them like they were going outta style. In the clinics i work at, people get really ticked off if the doc doesnt give them a script for something. A good example of that is antibiotics... Once Celebrex was pulled, the lawyers were buying TV and radio time to get their lawsuits set up. Here in Vegas, a firm was not only trying to get past celebrex users signed up, but also wanted bextra and even naproxen users to get signed up too. this was way before the congressional hearings.
TV advertising by pharm companies does raise the consumer knowledge on certain signs/symptoms that may have. however, even if the doctor tells them that have little to nothing wrong, they will almost always beg/cheat their way to a script. again, i make reference to the antibiotic situation.
We all know that all medications have side effects, and therefore, medications that are a higher risk should be used in extreme cases...
I can post more if anything needs explaining/defended. HAHA!!
TV advertising by pharm companies does raise the consumer knowledge on certain signs/symptoms that may have. however, even if the doctor tells them that have little to nothing wrong, they will almost always beg/cheat their way to a script. again, i make reference to the antibiotic situation.
We all know that all medications have side effects, and therefore, medications that are a higher risk should be used in extreme cases...
I can post more if anything needs explaining/defended. HAHA!!
