If english is a second language, def the first one. Even if it isn't, still the first one.
Reasons: In my opinion, Bio is the most applicable to anything you will do in D-School and if I were an AdCom I'd put more weight on Bio. RC is important too because you will be doing a butt ton of that and should be able to do it quickly! Next is Chem but only the broad concepts you need to know. OChem is the same but you need to know even less! PAT is questionable cuz I know peeps with crazy PAT scores who don't show it in simlab/clinic. QR is next to worthless.
The first one seems a bit more even and spread out but basically they are pretty much the same, your GPA, LOR's, interview, etc will make or break you.
The only reason I might choose #2 is cuz you don't have anything lower than an 18 in that one...which is nice for cut-offs