Secondary Hypoparathyroidism

[usmlesaga]

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Sorry in advance for making a new thread on this but i couldnt find what i wanted.

Does anyone know the causes of secondary hypoparathyroidism?

Thanks!

 

[ArcGurren]

Sorry in advance for making a new thread on this but i couldnt find what i wanted.

Does anyone know the causes of secondary hypoparathyroidism?

Thanks!

Hypercalcemia?

 

[wishingformore]

Would VIt D intoxication be a cause?

 

[raynor123456]

Hypervitaminosis D is a good one I think. Sarcoidosis.

 

[Rollo]

According to Goljan,

Malignancy-induced (Page 496 in 3rd edition)

Hypercalcemia in pregnancy induces hypocalcemia in fetus because PTH is suppressed

Page 493....under HypoPTH, Hypomagnesemia since magnesium is needed for adenylate cyclase, and he lists the causes for low magnesium there so...

 

[ArcGurren]

Would VIt D intoxication be a cause?

In theory yes; hypervitaminosis D would cause hypercalcemia and hyperphosphatemia, which would in turn lead to hypoparathyroidism.

Important clinical correlate to remember is that this is pretty rare in general, but it does happen in sarcoidosis because the macrophages in the granulomas express 1 alpha hydroxylase, which activates it like crazy.

 

[usmlesaga]

According to Goljan,

Page 493....under HypoPTH, Hypomagnesemia since magnesium is needed for adenylate cyclase, and he lists the causes for low magnesium there so...

Mg is a cofactor for PTH - so if Mg2+ is low so is PTH.

So, ok I guess in theory anything that causes increased Ca2+ would cause secondary hypoPTH?

Thanks for the responses everyone.