sequential interim analysis

This forum made possible through the generous support of SDN members, donors, and sponsors. Thank you.

MeghanHF

Member
10+ Year Member
5+ Year Member
15+ Year Member
Joined
Aug 12, 2005
Messages
118
Reaction score
0
Has anyone heard about this study? Does anyone see any flaws? Any other thoughts? I think it seems particularly useful for use in some clinical psych research, for example if there were few patients available to participate. Also, since it is unethical to create a control group that is entirely untreated, with this method you could create a situation for statistical comparison.

Statisticians at St. Jude Children's Research Hospital have developed a
new technique that allows researchers to statistically analyze results
of clinical trials. In it, all participants receive a new treatment and
none are assigned to a control group getting the existing treatment.
Instead, the treatment group is compared with a so-called "historical
control" composed of patients who received the existing treatment in a
previous study.
 
Top