Should We Really Prescribe Lithium?

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How comfortable are you prescribing lithium?

  • I am uncomfortable; I only prescribe it when there are no better alternatives.

    Votes: 0 0.0%

  • Total voters
    13

JIPsychiatry

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I'm wondering if anyone else feels similarly about Lithium. I am increasingly hesitant to prescribe lithium to anyone due to its vast collection of serious side effects (endocrine, cns, derm, renal, cardia, etc). Yes, I realize that it's always a question of benefit vs. risk, and I know that it's the "gold standard" for manic episodes. I know there is evidence for it reducing suicide. However, even with all of those benefits, it seems to me that long-term lithium therapy always results in some serious complications. I tend to favor other mood stabilizers because they appear to approach similar clinical benefit with fewer long-term complications. I have essentially stopped prescribing lithium, except for people who were already on it when they came to me. Are there any other prescribers who feel similarly, or am I going off the reservation here? I'm the only psychiatrist for a relatively small town, so I don't have many colleagues with which to compare prescribing styles. Please take my poll and provide a rationale in your response. Thanks.

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I'm wondering if anyone else feels similarly about Lithium. I am increasingly hesitant to prescribe lithium to anyone due to its vast collection of serious side effects (endocrine, cns, derm, renal, cardia, etc). Yes, I realize that it's always a question of benefit vs. risk, and I know that it's the "gold standard" for manic episodes. I know there is evidence for it reducing suicide. However, even with all of those benefits, it seems to me that long-term lithium therapy always results in some serious complications. I tend to favor other mood stabilizers because they appear to approach similar clinical benefit with fewer long-term complications. I have essentially stopped prescribing lithium, except for people who were already on it when they came to me. Are there any other prescribers who feel similarly, or am I going off the reservation here? I'm the only psychiatrist for a relatively small town, so I don't have many colleagues with which to compare prescribing styles. Please take my poll and provide a rationale in your response. Thanks.

I like prescribing lithium, but one reason I don't use it more is because it's so difficult for many patients to get level checked. If you work within a system it's much easier.....but a lot of patients aren't within that system. I'm thinking about an agency job I work, and in many cases there is no easy way to get those patients level checked.....because psych clinics are so disconnected from the rest of medicine in many cases, when we do things that require some medical oversight in the outpt world it is more difficult to arrange it. Obviously in primary care most large practices have an arrangement already set up with a lab, and the lab is often paying for the phleb to do all that stuff.
 
Most psychiatrists don't have a needed perspective on the degrees of extremes.

If you work in a long-term facility, expect to have patients where nothing, I mean nothing works. Clozapine? No. ECT? No.
In situations like this, you see lithium as needed because it's one of the best meds out there for bipolar disorder and it's highly augmenting for antipsychotics.

Most residents will never see this level of severity outside a long-term facility.

On the flip-side, most residents don't know how good Lamictal is as a med for weaker bipolar disorder because they don't have enough experience seeing patients with weaker bipolar II disorder or cyclothymia. No weight gain, cheap, and patients that are very compliant-this happens actually quite a bit in private practice.

The problem here is residencies tend to be in hospitals with majority Medicaid/Medicare because they're the people who finance residency salaries. This limits most residents into the community or university hospital in the middle of a downtown with Medicare/Medicaid only patients.

Several psychiatrists I see only prescribe one of a few of the possible meds out there and based on very limited reasoning. I've seen some even say "I like the color of the pill" or "it's my favorite medication, I give it to everyone." I wish I were joking.

I've worked in community mental health, private practice, long term and short term facilities, uber-expensive private institutions for the rich, academia, forensic, geriatric, an all-women facility, an all male facility, jails, state hospitals, community hospitals, university hospitals....

I still have the perspective that I am learning. Some people I know do one job and stick with it. They have blinders on from that one perspective, and they aren't even that good in that one specific setting. This can be dangerous not just clinically-because of the intellectual limitations and incest, but because you could be paid and treated like crap and not know it because had to just worked 10 minutes away you would've known what the other side was like.

I think one of the only settings off-hand that I haven't worked in is a child-psych facility, prison and the other being a pill-mill, but I don't want to do the latter. (Hmm, maybe right before I retire, so that way if they take my license it won't matter anyway---yes I am joking). That and wherever you can get sex-surrogates. Hey they're mentioned in textbooks for the treatment of non-physiological psychological erectile dysfunction, but hey, if they're supposed to be the treatment for that disorder why is it that no one ever seems to be able to refer anyone to them?

Point is-there's a proper place for every single medication given the level of severity and treatment resistance, that is unless you got a patient where none of them will work.

Lithium is a very good medication for several specific situations. I wouldn't put every single bipolar disordered person on it, but it's a great tool for treatment for worse cases and cases where you can't tell if it's a cluster-b vs a mood disorder vs ADHD vs GAD (that looks like bipolar disorder) because it being so efficacious, if the person has no side effects and no benefit whatsoever, it greatly pushes my opinion in crossing off bipolar disorder off the differential. If the patient is in good health, follows up for labwork, and is not at high risk for kidney damage, it also helps them as being a better candidate.
 
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your discomfort is misplaced. lithium is one of the few drugs we have that actually works. 1/3 of patients with classic manic depression get better with lithium monotherapy alone and often stay well for many years or never have another episode again. can't say that for our other treatments. it is the only treatment we have that reduces suicide independent of its effects on mood. conversely antidepressants have no effect and may increase suicidality in those under 25. the checking of levels and monitoring increasing adherence and probably contributes to its success. It is also the most effect augmentation agent in treatment-resistant depression (NNT=5). In TRD I use often very low doses and don't even monitor levels.

What's the alternative. Depakote has no evidence supporting its use in the maintenance treatment of bipolar disorder. (see BALANCE trial, but there are others too). Carbamazepine likewise has no evidence supporting its maintenance use from good RCTs. Lamotrigine alone isn't all that good for people with bipolar I and actually there isn't much evidence supporting its use in bipolar II either. So what you have left is antipsychotics with olanzapine and quetiapine having the best data for maintenance phase of bipolar disorder. They make you very fat. They cause zombification. They are associated with metabolic syndrome, tardive dyskinesia, and cerebral atrophy of unknown significance. lithium on the other hand is associated with neurogenesis and increased white matter, again of unknown significance.

Complications of lithium come as a result of improper monitoring. As long as people have good monitoring and don't have significant fluctuations in levels in the toxic range, the chances of renal disease are low. I do not use it in people with psoriasis. with monitoring, 1% of patients will develop renal failure. Even then, I've had patient insistent they want to stick with it and we've worked with a nephrologist to keep things safe. 10% will develop hypothyroidism. NDI is almost always reversible and is uncommon, much more common is polydipsia and polyuria without diabetes insipidus. Toxicity in overdose is overrated. It is actually quite hard to kill yourself with lithium because it's so toxic people typically throw up. Also nephrotoxicity is more likely with chronic supratherapeutic administration than with overdose. It has the best data guiding its use in pregnancy too.

I am very critical of psychiatric drugs in general but I think lithium is vastly underutilized. It is not appropriate for patients who will not be adherent as withdrawal is typically associated with a much worse course of illness and increased suicide rate than if never taken, or with those you can't monitor. Patients with more frequent episodes (so-called rapid-cyclers) do not respond as well to lithium nor those with mixed states. If you have a MDE (mania-depression-euthymia) course, response is better than DME course. Family history of lithium-responsiveness is also associated with good response. And it is my go to for treatment-resistant depression. In the US the suggested range is 0.8-1.2 but actually much of the European data (which predates the US data) shows 0.6-1.0 is reasonable and many people can be fine in the lower range. For treatment-resistant depression 0.4-0.6 is reasonable. I also give people a nice handout and a booklet to record their lithium levels and with instructions about med interactions, and things to be careful of (exercise, high altitude, hot days etc).

I also think we should prescribe TCAs more often for melancholic depression (amitriptyline is probably the most effective antidepressant) and MAOIs in treatment-resistant atypical depression, and clozapine in those who get some benefit from antipsychotics but not enough. if you get no benefit from another neuroleptic i am not sure there is much point in using clozapine. almost 15% of patients won't benefit from any antipsychotic at all and this has been associated with glutametergic dysregulation
 
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Most psychiatrists don't have a needed perspective on the degrees of extremes.

If you work in a long-term facility, expect to have patients where nothing, I mean nothing works. Clozapine? No. ECT? No.
In situations like this, you see lithium as needed because it's one of the best meds out there for bipolar disorder and it's highly augmenting for antipsychotics.

Most residents will never see this level of severity outside a long-term facility.

I know this obviously a non medical opinion, but I honestly cannot see how any Psychiatrist, when confronted with someone with severe Bipolar Disorder, could question the use of Lithium. I understand it can have serious side effects, and perhaps you might not pick it for a first line option, but to dismiss it completely? No, not if someone's illness is severe enough to warrant its use, not in my (albeit lay person's) opinion. I had a support group friend in the UK (her name was Emily) with severe treatment resistant Bipolar Disorder - in and out of long term Psychiatric care (at least half of those under section), numerous meds and med combinations, ECT, pretty much nothing worked, or it would work but cause serious medical side effects and the treatment would have to be discontinued. If I'd been one of Emily's caretakers at the time, and I'd heard a Doctor refusing to prescribe her Lithium, or questioning its use when it might have had some benefit, I think it would have taken me all my strength not to jump the table and cheerfully throttle the person. As it was in the last 6 months of Emily's life I think they had pretty much reached the point where they were starting to head into almost experimental territory in terms of meds and med combinations. Eventually it all just got too much for her, she wanted nothing more in the world than to just be well, and it wasn't happening. She committed suicide in 2006 at the age of 22. Beautiful girl, very talented award winning writer (some of her poems were published posthumously), incredibly missed by so many people.

I do realise this is coming from a very emotional point of view, but again I say, even as a lay person, the idea that a Psychiatrist wouldn't use everything in his or her arsenal, including Lithium, to treat severe Bipolar Disorder/Illness - no, sorry, that doesn't compute for me.
 
Experience using things like lithium is what makes us a specialty. If we don’t know how to use MAOIs, TCAs, clozaril, or lithium, might as well let the primary care guys do our job, or better yet, how about those psychologists from Illinois. LiCO3 is still number one for acute mania. The Abbott reps will mention mixed and rapid cycling with Depakote, but acute mania = LiCO3 (APA treatment guidelines, which are old and fading away, but still created by a bunch of old guys with experience).
 
which is an unfortunate reflection on our field
I like you, and I have a task for you. Look up literature on emapunil (XBD-173) and write up a report for me in layman's terms on what it is, what it does, and whether it could potentially help in benzo withdrawal. At least back in 2009 the lead researcher on this drug was Ruper Rupprecht. I tried contacting him to get info on his research (I am not intelligent enough to understand the literature, nor am I a psychiatrist), and he was rude to me (he uses like three titles in front of his name—he's German). This was his e-mail address, at least at the time: [email protected]-muenchen.de ; he's probably be more likely to talk to a fellow doctor.

You are going to single-handedly improve the field of psychiatry by writing this report for me. This drug might be dead in the water. But at least we'll know and advance the field. Thank you.
 
Although I use Lithium quite a bit, I understand where JIPsych is coming from. Some of the rates quoted in this thread are low. In my readings, with long term use, rates of hypothyroidism can be as high as 35%, NDI is around 20%, and there have been some reports indicating high rates of decreased kidney function (numbers escape me at the moment).

For the Bipolar II/ cyclothymia, I go with Lamictal first then Abilify if Lamictal doesn't work. For Bipolar I mania, I go with Lithium first, for a patient with primarily mixed/ bipolar depression I usually go with Seroquel first. Augment with Latuda if needed for bipolar depression. Usually try Zyprexa towards the end. This is generally speaking, obv different factors come into play (ability to get labs, BMI, suicidality, etc).

I generally stick with Lamictal, Lithium, Abilify, Seroquel, Zyprexa, and Latuda for bipolar patients considering those meds have some evidence of helping with bipolar depression which is where most of these patients live.
 
Thank you all for your thoughtful responses. I work outpatient where treatment-resistant cases have been less common, and perhaps that has tainted my view of efficacy vs benefit in my population. When I'm sure of a history of pronounced manic episodes, I do use lithium, but only with a lot of education to my patients. I've seen much more than a 10% rate of hypothyroidism, and my fair share of toxicity, which has made me increasingly hesitant to use it. Possibly my patient sample is just a couple of standard deviations away from the average, which has unnecessarily skewed my view of lithium. I'm sure I would have no qualms in prescribing it in a more controlled environment. One of my biggest concerns is poor patient compliance where they forget to come to the office for monitoring, or take a bunch of NSAIDs just before having a violent episode of gastroenteritis and end up with severe toxicity. I certainly appreciate the feedback. It is valuable, and I will be thinking of your responses tomorrow for some of my patients. Thank you.
 
I love LTG, very underused drug.

As for lithium, more and more I'm shying away from it especially for Bipolar II. On the other hand, I'm using it a heck of a lot at low dose for depression augmentation, irritability and impulsivity (300-600QHS) because it's just plain working...
 
That and wherever you can get sex-surrogates. Hey they're mentioned in textbooks for the treatment of non-physiological psychological erectile dysfunction, but hey, if they're supposed to be the treatment for that disorder why is it that no one ever seems to be able to refer anyone to them?.

Maybe sex-surrogacy just needs more awareness. Maybe we can include it in the new dance therapy sub-forum.
 
I'm only a first year psych resident, but I agree that Lithium definitely has it uses. I've seen plenty of patients who do really well on lithium. I don't see a reason why we can't use it as long as we are smart about it. There would be barely any drugs on the market if we shyed away from things that had bad side effects. Also another plus for lithium is that it is the only mood stabilizer on the $4 list. We work in a pretty underserved area and cost is something we really have to look at.
 
your discomfort is misplaced. lithium is one of the few drugs we have that actually works. 1/3 of patients with classic manic depression get better with lithium monotherapy alone and often stay well for many years or never have another episode again. can't say that for our other treatments. it is the only treatment we have that reduces suicide independent of its effects on mood. conversely antidepressants have no effect and may increase suicidality in those under 25. the checking of levels and monitoring increasing adherence and probably contributes to its success. It is also the most effect augmentation agent in treatment-resistant depression (NNT=5). In TRD I use often very low doses and don't even monitor levels.

What's the alternative. Depakote has no evidence supporting its use in the maintenance treatment of bipolar disorder. (see BALANCE trial, but there are others too). Carbamazepine likewise has no evidence supporting its maintenance use from good RCTs. Lamotrigine alone isn't all that good for people with bipolar I and actually there isn't much evidence supporting its use in bipolar II either. So what you have left is antipsychotics with olanzapine and quetiapine having the best data for maintenance phase of bipolar disorder. They make you very fat. They cause zombification. They are associated with metabolic syndrome, tardive dyskinesia, and cerebral atrophy of unknown significance. lithium on the other hand is associated with neurogenesis and increased white matter, again of unknown significance.

Complications of lithium come as a result of improper monitoring. As long as people have good monitoring and don't have significant fluctuations in levels in the toxic range, the chances of renal disease are low. I do not use it in people with psoriasis. with monitoring, 1% of patients will develop renal failure. Even then, I've had patient insistent they want to stick with it and we've worked with a nephrologist to keep things safe. 10% will develop hypothyroidism. NDI is almost always reversible and is uncommon, much more common is polydipsia and polyuria without diabetes insipidus. Toxicity in overdose is overrated. It is actually quite hard to kill yourself with lithium because it's so toxic people typically throw up. Also nephrotoxicity is more likely with chronic supratherapeutic administration than with overdose. It has the best data guiding its use in pregnancy too.

I am very critical of psychiatric drugs in general but I think lithium is vastly underutilized. It is not appropriate for patients who will not be adherent as withdrawal is typically associated with a much worse course of illness and increased suicide rate than if never taken, or with those you can't monitor. Patients with more frequent episodes (so-called rapid-cyclers) do not respond as well to lithium nor those with mixed states. If you have a MDE (mania-depression-euthymia) course, response is better than DME course. Family history of lithium-responsiveness is also associated with good response. And it is my go to for treatment-resistant depression. In the US the suggested range is 0.8-1.2 but actually much of the European data (which predates the US data) shows 0.6-1.0 is reasonable and many people can be fine in the lower range. For treatment-resistant depression 0.4-0.6 is reasonable. I also give people a nice handout and a booklet to record their lithium levels and with instructions about med interactions, and things to be careful of (exercise, high altitude, hot days etc).

I also think we should prescribe TCAs more often for melancholic depression (amitriptyline is probably the most effective antidepressant) and MAOIs in treatment-resistant atypical depression, and clozapine in those who get some benefit from antipsychotics but not enough. if you get no benefit from another neuroleptic i am not sure there is much point in using clozapine. almost 15% of patients won't benefit from any antipsychotic at all and this has been associated with glutametergic dysregulation
I'm surprised that I missed this thread before, but I vote for this as the single "correct" answer to the OP's question.
 
I think Psychiatrists don't prescribe lithium as a first-line if they see severe mania, furthermore cyclothymic due to the lack of time they've had with the patient. I personally think that bipolar could be treated with other medications.However,if she/he is treatment resistant or the medications aren't able to fix the symptom,Lithium would be the best option. Of course, the other problem is Getting the dude to actually take the medications due to the acute side effects of it, which is another factor towards prescribing lithium
-Non medical student here
 
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