"I hand them the article of exogenous opioid lack of effect in FMS."
Totally agree, but why stop with fibro? I also hand patients Martell's study on opioids for CLBP and explain that they don't work for that either. When you closely scrutinize the main articles evaluated by Martell (Hale et al, Jamison et al) you can clearly see that opioids are a worthless treatment for CLBP. In fact, they are quite detrimental when you consider the side effects and abuse potential.
It's a good opening salvo in the argument for using opioids for one process and not another. I'll go nuclear.
CLBP is a peripheral process that leads to peripheral and central sensitization.
FMS is a central process that may lead to central and peripheral sensitization. Opioids have traditionally been thought of and studied as ineffective for central pain states. (I believe FMS is a central pain state, and the literature bears this out).
The Journal of Neuroscience, September 12, 2007, 27(37):10000-10006;
JNEUROSCI.2849-07.2007 Neurobiology of Disease
Decreased Central µ-Opioid
Receptor Availability in Fibromyalgia
Richard E. Harris,1 Daniel J. Clauw,1 David J. Scott,2
Samuel A. McLean,3 Richard H. Gracely,1
and Jon-Kar Zubieta2,4
Most of what we know about FMS comes from Clauw's work.
The abstract:
The underlying neurophysiology of acute pain is fairly well characterized, whereas the central mechanisms operative in chronic pain states are less well understood. Fibromyalgia (FM), a common chronic pain condition characterized by widespread pain, is thought to originate largely from altered central neurotransmission. We compare a sample of 17 FM patients and 17 age- and sex-matched healthy controls, using µ-opioid receptor (MOR) positron emission tomography. We demonstrate that FM patients display reduced MOR binding potential (BP) within several regions known to play a role in pain modulation, including the nucleus accumbens, the amygdala, and the dorsal cingulate. MOR BP in the accumbens of FM patients was negatively correlated with affective pain ratings. Moreover, MOR BP throughout the cingulate and the striatum was also negatively correlated with the relative amount of affective pain (McGill, affective score/sensory score) within these patients. These findings indicate altered endogenous opioid analgesic activity in FM and suggest a possible reason for why exogenous opiates appear to have reduced efficacy in this population.