So, when did Glycine and Phenylalanine switch hydrophobicness?

[johnwandering]

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The older BR books had Glycine as hydrophobic and phenylalanine as semi-hydrophobic.
The newer book has them now switched.

I was wondering what the more conventional classifications were, and their implications?

 

[EnginrTheFuture]

The older BR books had Glycine as hydrophobic and phenylalanine as semi-hydrophobic.
The newer book has them now switched.

I was wondering what the more conventional classifications were, and their implications?

They probably switched because labeling phenylalanine as semi-hydrophobic would be ridiculous. It's side chain is a sizable benzene ring, it doesn't get much more non-polar than that. Water looks at phenylalanine and goes 👎. Glycine doesn't have much of a side group at all... it's just a hydrogen. Thus the hydrophobicity of the side group is a little more complicated. Generally people consider it fit to work its way into both hydrophilic and hydrophobic environments.