solublizing drugs

[TotalKayOs]

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over the summer i forgot a lot of stuff that i learned last year, and now i'm trying to review it but it's not clicking this time. so if anyone can hep me clear this up it would be great:

when something is made into a salt form it has to be disolved into it's opposit, right? an acidic drug needs to be dissloved in a weak base and vise vera? so morphine a basic drug needs to be dissolved in HCl. and phenytoin a weak acid needs to dissloved in a stong base like NaOH, right?

so now if i were to put morphine HCl in a medium that had a pH of 7, would the pH drop to below 7?

thirdly, a weak acid/strong base drug can notbe mixed with a weak base/ strong acid drug in a bag or line becasue they would precipate each other out? thanks for any help sorry for any spelling mistakes.

 

[spacecowgirl]

I'm no expert in pH and pKas, sorry but I always remember that acidic drugs need to be combined with the "ium" salts - sodium, potassium, calcium, and to a lesser extent lithium, aluminum, and zinc (ok, doesn't fit my pneumonic device there).

I also know a strong acid + weak base = acidic salt
strong acid + strong base = neutral salt
weak acid+ strong base = alkaline salt

So I guess you would want to make a polarized compound so that it would be more water soluble as opposed to something without a charge. Sorry I can't help you anymore than that 🙂

 

[spacecowgirl]

oh and you're right - too much free acid or base can precipitate out

 

[TotalKayOs]

thanks for the help.