Someone please help me!!-What is a subepithelial hump??

[jellygreen2001]

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Hi everyone,

I am studying renal path and am getting totally confused about the difference between a subepithelium vs subendothelium hump. Where are each one located? The subendo is under the blood vessel cells right? but what epithelium are they talking about?I would greatly appreciate your help

Thanks in advance

 

[Dedikated2liftn]

Something I give to your mama after foreplay! 🙂

 

[rachmoninov3]

subepithelial humps are seen in relation to post-infectious glomerulonephritis, and are associated with IgG (usually after strep infectioun, and the patient will so Anti strep antibodies). The antibody binds to the strep antigen, and it almost gets through the glomerulofiltration, but it's too big, and it gets stuck under the podocyte foot pads and causes inflammation.

try http://library.med.utah.edu/WebPath/COW/COW070.html

And good luck, renal path sucks!

 

[lilnoelle]

Per Goljan in RR Path (the pictures make it quite a bit easier to understand....) You have to be looking at an electron microscopic picture to see the difference. Subendothelial immunocomplex deposits - the band of electron-dense material extends around the glomerular basement membrane and hugs the interface of the membrane with the capillary lumen. The immune deposits will be beneath the nucleus of the endothelial cell (it gets through the fenestra but thats as far as it can get.) A thin rim of normal basement membrane separates the deposits from the epithelial side of the membrane. A good example of this is diffuse proliferative glomerulonephritis (also Membranoproliferative Glomerulonephritis type I).

Subepithelial immunocomplex deposits - electron dense deposits are located directy beneath the visceral epithelial cells. (these deposits get through the fenestrae and basement membrane, but the podocyte feet processes of the visceral epithelial cells prevent them from going further). Good examples of this is poststreptococcal glomerulonephritis and diffuse membranous glomerulopathy.

I'm assuming the main difference between the two is the size (and perhaps charge) of the immune complex - but I can't say that diffinitively.

Robbins Pathology, figure 20-10 shows the difference quite well. (if you have it)

 

[virilep]

Hi everyone,

I am studying renal path and am getting totally confused about the difference between a subepithelium vs subendothelium hump. Where are each one located? The subendo is under the blood vessel cells right? but what epithelium are they talking about?I would greatly appreciate your help

Thanks in advance

I want to say that this is actually an errata. There's another thread about it.