WiseOne

7+ Year Member
Jun 6, 2011
136
87
Status
This may or may not be a stupid thread.

I happened to be reading on how anticholinergic medication can increase the risk of dementia long-term, even after a very short amount of use. I was thinking, this must mean that the brain doesn't fully reverse whatever changes are induced by anticholinergics on the cholinergic system. I am not sure what the exact mechanism is. I was thinking by analogy, how antidepressants are known to have inhibitory effects on dopaminergic signaling, and that some people tend to report apparent problems long after discontinuation. I am not well versed in neuroscience so I was wondering if the brains response to SSRIs dopaminergic effects could be anything similar to its response to anticholinergic med effects? Thanks.
 
Last edited:

wolfvgang22

Gold Donor
15+ Year Member
Jun 15, 2004
1,531
2,061
Status
Attending Physician
It's not a stupid thread. I don't think anybody really knows the answer based on my reading of the literature, though there is some speculation and lots of anecdotes. This is a ripe area for additional investigation.
 
About the Ads

thoffen

Member
10+ Year Member
Aug 14, 2006
1,326
657
Status
Attending Physician
Also agree that it's not a stupid thread. And also that a clear answer is incredibly difficult to establish unless the connection is pretty robust. That said, if no one is looking into that hypothesis then an important finding might be missed.
 
About the Ads